Biomaterial Database

Comparative aspects of adrenergic receptors in the hearts of lower vertebrates. 1983

J A Ask

The cardiac adrenoceptors of lower vertebrates were characterized in atrial preparations. Adrenaline (A) potentiated the force and frequency of contraction in the spontaneously beating atria of the frog, trout and flounder and in electrically paced atrial strips from the shark. The inotropic responses of A were most pronounced at the lower temperatures for the frog and trout, while A enhanced frequency to a greater extent at higher temperatures in the frog atria. Atrial alpha-receptors activated by A at 8 degrees C could not be detected in any of the species under study. The apparent affinities for the inotropic and chronotropic responses of agonist in the frog (15 degrees C) and trout (8 degrees C) atria were: Iso greater than Sal greater than or equal to A greater than NA. A cocaine-sensitive uptake for A and NA was apparent in these atria, consistent with sympathetic innervation. The affinities for the catecholamines in the flounder and shark atria were not increased by cocaine, in accordance with absence of sympathetic innervation of the atria in these species. These atria were also insensitive to corticosterone. The affinities for A and NA were on the other hand higher in the sympathetically non-innervated atria of the flounder than in the innervated atria of the frog and trout. The apparent orders of relative affinities for agonists were Iso greater than A = NA greater than Sal for the flounder, and of the relative potencies Iso = A greater than NA greater than Sal for the shark atrium. The results are consistent with the hypothesis that catecholamines enhance cardiac performance in lower vertebrates chiefly via "adrenaline" receptors which resemble the beta 2-type of mammalian adrenoceptors in many respects. Unlike that in mammals, cardiac adrenaline receptors in the frog and trout are activated by the sympathetic neurotransmitter ("innervated" receptors). On the other hand, the adrenaline receptors of the flounder and shark are responding to the circulating catecholamines ("humoral" receptors). However, the flounder atrium, with equal affinities for A and NA, appears as an exception to the rule by having a mixed population of humoral beta 1- and beta 2-adrenoceptors, indicating a role for circulating NA in cardiac regulation in this species.

UI	MeSH Term	Description	Entries
D009200	Myocardial Contraction	Contractile activity of the MYOCARDIUM.	Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D011896	Rana temporaria	A species of the family Ranidae occurring in a wide variety of habitats from within the Arctic Circle to South Africa, Australia, etc.	European Common Frog,Frog, Common European,Common European Frog,Common Frog, European,European Frog, Common,Frog, European Common
D011941	Receptors, Adrenergic	Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.	Adrenergic Receptors,Adrenoceptor,Adrenoceptors,Norepinephrine Receptor,Receptors, Epinephrine,Receptors, Norepinephrine,Adrenergic Receptor,Epinephrine Receptors,Norepinephrine Receptors,Receptor, Adrenergic,Receptor, Norepinephrine
D002395	Catecholamines	A general class of ortho-dihydroxyphenylalkylamines derived from TYROSINE.	Catecholamine,Sympathin,Sympathins
D005399	Fishes	A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species
D013696	Temperature	The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.	Temperatures
D014714	Vertebrates	Animals having a vertebral column, members of the phylum Chordata, subphylum Craniata comprising mammals, birds, reptiles, amphibians, and fishes.	Vertebrate