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It has been shown previously that trypsinogen and its activation peptide but not trypsin decreased gastric secretion. The purpose of this work was to study the dose-action relation between the intraduodenal infusion of trypsinogen and gastric secretion. Three dogs provided with gastric and duodenal Thomas fistulae were stimulated by continuous i.v. perfusion of porcine gastrin I-II (6 microgram kg-1 h-1). Pancreatic juice was diverted to the exterior and gastric secretion was collected. Upon reaching a gastric secretory plateau, porcine trypsinogen was infused intraduodenally at doses of 5, 10, 20, 40, 80 and 160 mg. Each test was continued for a further 60 min. Control was made with isotonic saline. There was a dose-related inhibition of the gastrin-stimulated gastric acid output. This inhibition reached a maximum of 50% with 40 mg of intraduodenal trypsinogen, showing no increase with higher doses.
J P Mendes de Oliveira, and
P Demol, and
M V Singer, and
M A Devaux, and
O M Tiscornia, and
H Sarles
January 1973,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
J P Mendes de Oliveira, and
P Demol, and
M V Singer, and
M A Devaux, and
O M Tiscornia, and
H Sarles
November 1974,
Gut,
J P Mendes de Oliveira, and
P Demol, and
M V Singer, and
M A Devaux, and
O M Tiscornia, and
H Sarles
August 1982,
The American journal of physiology,
J P Mendes de Oliveira, and
P Demol, and
M V Singer, and
M A Devaux, and
O M Tiscornia, and
H Sarles
June 1948,
The American journal of physiology,
J P Mendes de Oliveira, and
P Demol, and
M V Singer, and
M A Devaux, and
O M Tiscornia, and
H Sarles
February 1952,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J P Mendes de Oliveira, and
P Demol, and
M V Singer, and
M A Devaux, and
O M Tiscornia, and
H Sarles
January 1978,
Gastroenterologia Japonica,
J P Mendes de Oliveira, and
P Demol, and
M V Singer, and
M A Devaux, and
O M Tiscornia, and
H Sarles
July 1973,
The British journal of surgery,
J P Mendes de Oliveira, and
P Demol, and
M V Singer, and
M A Devaux, and
O M Tiscornia, and
H Sarles
April 1972,
The British journal of surgery,
J P Mendes de Oliveira, and
P Demol, and
M V Singer, and
M A Devaux, and
O M Tiscornia, and
H Sarles
September 1974,
The British journal of surgery,
J P Mendes de Oliveira, and
P Demol, and
M V Singer, and
M A Devaux, and
O M Tiscornia, and
H Sarles
September 1987,
Journal of veterinary pharmacology and therapeutics,
