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Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. 1982
A Eva, and
K C Robbins, and
P R Andersen, and
A Srinivasan, and
S R Tronick, and
E P Reddy, and
N W Ellmore, and
A T Galen, and
J A Lautenberger, and
T S Papas, and
E H Westin, and
F Wong-Staal, and
R C Gallo, and
S A Aaronson
Polyadenylated RNAs of certain human tumour cell lines are shown to contain transcripts related to the cell-derived transforming onc genes of molecularly cloned primate, murine or avian transforming retrovirus genomes. Thus, analogues of retroviral transforming genes are both present and frequently expressed in human neoplastic cells.
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