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The ventral spinal cord content of several neuronally localised peptides was measured after treatment with a number of drugs which deplete spinal cord monoamines. Reserpine and tetrabenazine, but not p-chlorophenylalanine caused a partial depletion of ventral spinal cord substance P (SP) and thyrotropin-releasing hormone (TRH). Two other peptides, methionine-enkephalin and somatostatin were not depleted by any of the drugs. The rates of loss and recovery of SP and TRH after reserpine and tetrabenazine were different from that of 5-hydroxytryptamine (5-HT), though in the ventral spinal cord these two peptides probably coexist with 5-HT in the terminals of bulbospinal neurones. The results are discussed in relation to the possible costorage of SP and TRH with 5-HT in the same vesicles in nerve terminals in the ventral spinal cord.
R F Gilbert, and
G W Bennett, and
C A Marsden, and
P C Emson
October 1972,
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R F Gilbert, and
G W Bennett, and
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P C Emson
April 1984,
Proceedings of the National Science Council, Republic of China. Part B, Life sciences,
R F Gilbert, and
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P C Emson
February 2008,
Neuroscience bulletin,
R F Gilbert, and
G W Bennett, and
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February 1978,
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R F Gilbert, and
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C A Marsden, and
P C Emson
September 1988,
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R F Gilbert, and
G W Bennett, and
C A Marsden, and
P C Emson
February 1977,
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R F Gilbert, and
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P C Emson
June 1996,
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R F Gilbert, and
G W Bennett, and
C A Marsden, and
P C Emson
December 1977,
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R F Gilbert, and
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C A Marsden, and
P C Emson
February 1989,
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R F Gilbert, and
G W Bennett, and
C A Marsden, and
P C Emson
September 1984,
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