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The concentrations of dopamine (DA) norepinephrine (NE), serotonin (5HT) and their metabolites, HVA, DOPAC, MHPG-SO4 and 5HIAA were measured in several brain areas of rats aged 4, 18 and 29 months. Dopamine and its metabolites showed a decline, statistically correlated with age, in all the dopaminergic areas considered, indicating that this system is profoundly affected in the senescent rat. The changes in the noradrenergic system were more complex. This neurotransmitter was reduced in spinal cord and in limbic area, but was not modified in hippocampus, cerebellum, striatum and s. nigra. In cortex, MHPG-SO4, the main NE metabolite, showed a significantly age-related increase. Tyrosine hydroxylase (TH) activity was low in striatum, and brainstem but not in hypothalamus of aged rats. Neither 5HT nor its metabolites was affected by age. The results indicate that central catecholaminergic systems are markedly affected in senescent rats.
F Ponzio, and
G Calderini, and
G Lomuscio, and
G Vantini, and
G Toffano, and
S Algeri
September 1989,
Mechanisms of ageing and development,
F Ponzio, and
G Calderini, and
G Lomuscio, and
G Vantini, and
G Toffano, and
S Algeri
July 1989,
Journal of pharmacobio-dynamics,
F Ponzio, and
G Calderini, and
G Lomuscio, and
G Vantini, and
G Toffano, and
S Algeri
April 2001,
Clinical and experimental pharmacology & physiology,
F Ponzio, and
G Calderini, and
G Lomuscio, and
G Vantini, and
G Toffano, and
S Algeri
June 1989,
Neuroscience letters,
F Ponzio, and
G Calderini, and
G Lomuscio, and
G Vantini, and
G Toffano, and
S Algeri
September 1998,
Biochimica et biophysica acta,
F Ponzio, and
G Calderini, and
G Lomuscio, and
G Vantini, and
G Toffano, and
S Algeri
March 2007,
Neuroscience,
F Ponzio, and
G Calderini, and
G Lomuscio, and
G Vantini, and
G Toffano, and
S Algeri
July 1982,
Life sciences,
F Ponzio, and
G Calderini, and
G Lomuscio, and
G Vantini, and
G Toffano, and
S Algeri
June 1983,
Toxicology letters,
F Ponzio, and
G Calderini, and
G Lomuscio, and
G Vantini, and
G Toffano, and
S Algeri
January 1989,
The Journal of pharmacology and experimental therapeutics,
F Ponzio, and
G Calderini, and
G Lomuscio, and
G Vantini, and
G Toffano, and
S Algeri
December 1995,
Neurochemical research,
