-transparent.png){kind=logo}
In this study, the effects of 5-aza-2'-deoxycytidine on differentiation of human leukemic cells in primary suspension culture are reported for the first time. Morphological and functional differentiation was induced in cells from two acute monoblastic leukemias and two of three acute myeloid leukemias following repeated exposures to 1 mumol/L 5-aza-2'-deoxycytidine. The observation that nontoxic concentrations of the drug are able to induce the in vitro differentiation of both monoblastic and myeloblastic leukemic cells into mature elements may encourage the exploitation of the differentiating properties of 5-aza-2'-deoxycytidine in chemotherapy protocols for acute non-lymphoblastic leukemias.
A Pinto, and
V Attadia, and
A Fusco, and
F Ferrara, and
O A Spada, and
P P Di Fiore
January 1985,
Leukemia research,
A Pinto, and
V Attadia, and
A Fusco, and
F Ferrara, and
O A Spada, and
P P Di Fiore
January 1998,
Cancer chemotherapy and pharmacology,
A Pinto, and
V Attadia, and
A Fusco, and
F Ferrara, and
O A Spada, and
P P Di Fiore
January 1990,
Leukemia research,
A Pinto, and
V Attadia, and
A Fusco, and
F Ferrara, and
O A Spada, and
P P Di Fiore
June 1992,
Anti-cancer drugs,
A Pinto, and
V Attadia, and
A Fusco, and
F Ferrara, and
O A Spada, and
P P Di Fiore
October 1990,
Cancer letters,
A Pinto, and
V Attadia, and
A Fusco, and
F Ferrara, and
O A Spada, and
P P Di Fiore
May 1993,
Leukemia,
A Pinto, and
V Attadia, and
A Fusco, and
F Ferrara, and
O A Spada, and
P P Di Fiore
May 1993,
Leukemia,
A Pinto, and
V Attadia, and
A Fusco, and
F Ferrara, and
O A Spada, and
P P Di Fiore
January 1985,
Pharmacology & therapeutics,
A Pinto, and
V Attadia, and
A Fusco, and
F Ferrara, and
O A Spada, and
P P Di Fiore
May 2010,
Archives of oral biology,
A Pinto, and
V Attadia, and
A Fusco, and
F Ferrara, and
O A Spada, and
P P Di Fiore
December 1989,
Bone marrow transplantation,
