BIOMAT Database Logo BIOMAT Database Logo

Five-year survival of patients with disseminated nonseminomatous testicular cancer treated with cisplatin, vinblastine, and bleomycin. 1984

G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo

Ninety-one patients with disseminated testicular non-seminomas were treated with 3 to 4 cycles of cisplatin, vinblastine, and bleomycin (PVB) induction chemotherapy followed by cisplatin and vinblastine maintenance therapy for 1 year. The follow-up of these patients ranges from 24 to 66 months. Forty-nine (54%) patients achieved complete remission by chemotherapy alone and 14 (15%) were rendered free of tumor by surgery after chemotherapy, for a total complete remission rate of 69%. Three complete responders relapsed within 13 months, and two died. One additional complete responder died of a noncancer-related cause. One of the surgical complete responders relapsed and died. Overall, 58 (64%) patients remain free of disease. The 5-year survival is 95% for complete responders, 32% for partial responders, and 72% overall. This combination regimen has significantly improved the survival of disseminated testicular cancer patients, equaling that of Stage II patients in older literature.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009362 Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. Metastase,Metastasis,Metastases, Neoplasm,Metastasis, Neoplasm,Neoplasm Metastases,Metastases
D001761 Bleomycin A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. BLEO-cell,Blanoxan,Blenoxane,Bleolem,Bleomicina,Bleomycin A(2),Bleomycin A2,Bleomycin B(2),Bleomycin B2,Bleomycin Sulfate,Bleomycins,Bleomycinum Mack,Bléomycine Bellon,BLEO cell,BLEOcell,Bellon, Bléomycine,Mack, Bleomycinum,Sulfate, Bleomycin
D002822 Choriocarcinoma A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL). Choriocarcinomas
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo
Vinblastine, cisplatin and bleomycin treatment of advanced nonseminomatous testicular tumors.
January 1990, Neoplasma,
G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo
Sequential combination chemotherapy with vinblastine-bleomycin and doxorubicin-cis-dichlorodiammineplatinum(II) in disseminated nonseminomatous testicular cancer.
January 1980, Cancer treatment reports,
G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo
Successful treatment of good-risk disseminated testicular cancer with cisplatin, bleomycin, and reduced-dose vinblastine.
June 1986, Cancer,
G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo
Acute nonlymphocytic leukemia 5 years after treatment with cisplatin, vinblastine, and bleomycin for disseminated testicular cancer.
March 1986, Cancer,
G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo
Results of adjuvant surgery in patients with stage III and IV nonseminomatous testicular tumors after cisplatin-vinblastine-bleomycin chemotherapy.
August 1988, Journal of surgical oncology,
G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo
Comparison of cisplatin + bleomycin + either vinblastine or VP-16 in disseminated testicular cancer: a preliminary report.
January 1984, Progress in clinical and biological research,
G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo
Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer.
September 1977, Annals of internal medicine,
G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo
Cisplatin, vinblastine and bleocin in the treatment of disseminated testicular cancer.
January 1993, International urology and nephrology,
G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo
Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. 1997.
February 2002, The Journal of urology,
G Stoter, and C P Vendrik, and A Struyvenberg, and D T Sleyfer, and R Vriesendorp, and H Schraffordt Koops, and A T van Oosterom, and W W ten Bokkel Huinink, and H M Pinedo
Early resection of residual tumor during cisplatin, vinblastine, bleomycin combination chemotherapy in stage III and bulky stage II nonseminomatous testicular cancer.
July 1985, Cancer,
Copied contents to your clipboard!