-transparent.png){kind=logo}
Effects of arotinolol on dog coronary arteries were investigated in vitro. In distal portions of left circumflex coronary arteries contracted with 3 X 10(-2)M KCl, norephinephrine relaxed the strips in a concentration-dependent fashion. Propranolol (10(-6)M) converted the norepinephrine-induced relaxations to contractions, and arotinolol (10(-6)-10(-5)M) inhibited the relaxations induced by norepinephrine in a concentration-dependent manner. In proximal portions of the strips after potassium-contracture, norephinephrine produced concentration-dependent contractions which were augmented by propranolol (10(-6)M) and inhibited by arotinolol (10(-6)-10(-5)M). These results suggest that arotinolol has an alpha-adrenoceptor blocking activity in addition to a beta-adrenoceptor blocking action in dog coronary arteries.
M Sakanashi, and
Y Miyamoto, and
H Ito, and
S Takeo, and
K Noguchi, and
T Higa
November 1983,
Japanese heart journal,
M Sakanashi, and
Y Miyamoto, and
H Ito, and
S Takeo, and
K Noguchi, and
T Higa
October 1984,
Archives internationales de pharmacodynamie et de therapie,
M Sakanashi, and
Y Miyamoto, and
H Ito, and
S Takeo, and
K Noguchi, and
T Higa
August 1983,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
M Sakanashi, and
Y Miyamoto, and
H Ito, and
S Takeo, and
K Noguchi, and
T Higa
February 1982,
Radioisotopes,
M Sakanashi, and
Y Miyamoto, and
H Ito, and
S Takeo, and
K Noguchi, and
T Higa
October 1985,
Archives internationales de pharmacodynamie et de therapie,
M Sakanashi, and
Y Miyamoto, and
H Ito, and
S Takeo, and
K Noguchi, and
T Higa
May 1985,
Japanese heart journal,
M Sakanashi, and
Y Miyamoto, and
H Ito, and
S Takeo, and
K Noguchi, and
T Higa
February 1983,
Archives internationales de pharmacodynamie et de therapie,
M Sakanashi, and
Y Miyamoto, and
H Ito, and
S Takeo, and
K Noguchi, and
T Higa
November 1975,
Experientia,
M Sakanashi, and
Y Miyamoto, and
H Ito, and
S Takeo, and
K Noguchi, and
T Higa
October 1982,
International journal of clinical pharmacology, therapy, and toxicology,
M Sakanashi, and
Y Miyamoto, and
H Ito, and
S Takeo, and
K Noguchi, and
T Higa
March 1984,
Canadian journal of physiology and pharmacology,
