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Passive cutaneous anaphylaxis (PCA) was produced in the rat with mouse IgE-rich antiserum. The effect of drugs on the PCA-induced skin histamine decrease and leakage of protein-bound dye was studied. Salbutamol (0.5 mg/kg i.v. or 1.0 mg/kg s.c.) and cromoglycate (10 mg/kg i.v.) significantly inhibited the skin histamine decrease. A combination of salbutamol (0.5 mg/kg i.v. or 1.0 mg/kg s.c.) and aminophylline (25 mg/kg i.v. or 75 mg/kg s.c.) had an additive or greater than additive effect on the histamine decrease. Salbutamol (1.0 mg/kg s.c.) inhibited the dye leakage markedly, and aminophylline (75 mg/kg s.c.) slightly. These results indicate that the decrease in the skin histamine content is useful as an index of the in vivo inhibitory effect of antiallergic drugs on the antigen-induced histamine release.
H Yokoyama, and
K Shimamura, and
K Saeki
December 1968,
Lancet (London, England),
H Yokoyama, and
K Shimamura, and
K Saeki
November 1968,
Lancet (London, England),
H Yokoyama, and
K Shimamura, and
K Saeki
June 1969,
Arerugi = [Allergy],
H Yokoyama, and
K Shimamura, and
K Saeki
October 1977,
Biulleten' eksperimental'noi biologii i meditsiny,
H Yokoyama, and
K Shimamura, and
K Saeki
April 1988,
Agents and actions,
H Yokoyama, and
K Shimamura, and
K Saeki
May 1981,
Planta medica,
H Yokoyama, and
K Shimamura, and
K Saeki
September 1977,
Hiroshima journal of medical sciences,
H Yokoyama, and
K Shimamura, and
K Saeki
January 1971,
International archives of allergy and applied immunology,
H Yokoyama, and
K Shimamura, and
K Saeki
January 1990,
International archives of allergy and applied immunology,
H Yokoyama, and
K Shimamura, and
K Saeki
November 1958,
Quarterly review of allergy and applied immunology,
