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A series of seven monoclonal antibodies was produced against the T-lineage-specific 50 kd T11 sheep erythrocyte rosette (SRBC) receptor protein in order to define the function of the molecule. Three distinct epitopes were detected: T11(1), the SRBC binding site expressed on all T lymphocytes and thymocytes; T11(2), an epitope unrelated to the SRBC binding site but with a similar distribution; and T11(3), a neo-epitope expressed only upon T-cell activation. Simultaneous triggering of T11(2) and T11(3) epitopes by monoclonal antibodies induces T lymphocytes to proliferate and mediate their functional programs in the absence of antigen and/or antigen-presenting cells. This antigen-independent mode of triggering is distinct from that involving the T3-Ti antigen receptor complex and represents an alternate pathway of T-cell activation. Given that T11 is the earliest T-lineage surface glycoprotein to appear in thymic ontogeny and is thus expressed before T3-Ti, the former may be involved in clonal expansion and/or differentiation during early development.
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R E Hussey, and
M Fabbi, and
D Fox, and
O Acuto, and
K A Fitzgerald, and
J C Hodgdon, and
J P Protentis, and
S F Schlossman, and
E L Reinherz
February 1988,
Immunology,
S C Meuer, and
R E Hussey, and
M Fabbi, and
D Fox, and
O Acuto, and
K A Fitzgerald, and
J C Hodgdon, and
J P Protentis, and
S F Schlossman, and
E L Reinherz
January 1985,
Nature,
S C Meuer, and
R E Hussey, and
M Fabbi, and
D Fox, and
O Acuto, and
K A Fitzgerald, and
J C Hodgdon, and
J P Protentis, and
S F Schlossman, and
E L Reinherz
May 1987,
Journal of immunology (Baltimore, Md. : 1950),
S C Meuer, and
R E Hussey, and
M Fabbi, and
D Fox, and
O Acuto, and
K A Fitzgerald, and
J C Hodgdon, and
J P Protentis, and
S F Schlossman, and
E L Reinherz
March 1985,
Journal of immunology (Baltimore, Md. : 1950),
S C Meuer, and
R E Hussey, and
M Fabbi, and
D Fox, and
O Acuto, and
K A Fitzgerald, and
J C Hodgdon, and
J P Protentis, and
S F Schlossman, and
E L Reinherz
July 1994,
International archives of allergy and immunology,
S C Meuer, and
R E Hussey, and
M Fabbi, and
D Fox, and
O Acuto, and
K A Fitzgerald, and
J C Hodgdon, and
J P Protentis, and
S F Schlossman, and
E L Reinherz
June 1987,
Behring Institute Mitteilungen,
S C Meuer, and
R E Hussey, and
M Fabbi, and
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K A Fitzgerald, and
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E L Reinherz
October 1989,
Cellular immunology,
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R E Hussey, and
M Fabbi, and
D Fox, and
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K A Fitzgerald, and
J C Hodgdon, and
J P Protentis, and
S F Schlossman, and
E L Reinherz
March 1987,
Journal of immunology (Baltimore, Md. : 1950),
S C Meuer, and
R E Hussey, and
M Fabbi, and
D Fox, and
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K A Fitzgerald, and
J C Hodgdon, and
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S F Schlossman, and
E L Reinherz
January 1988,
Journal of immunology (Baltimore, Md. : 1950),
S C Meuer, and
R E Hussey, and
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K A Fitzgerald, and
J C Hodgdon, and
J P Protentis, and
S F Schlossman, and
E L Reinherz
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