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Lymphocyte subsets were enumerated in a group of 31 patients with aplastic anemia. Abnormal numbers of immunoregulatory T-cells were found in some patients: 26% of them showed a reversed helper/suppressor ratio. Seven of 18 patients showed significantly decreased proliferation in response to PWM; this hyporesponsiveness was present in 75% of patients with a reversed helper/suppressor ratio and in 10% of those with a normal helper/suppressor ratio (R = 0.66, P = 0.008). Eight of 18 patients showed suppressor activity over PWM-induced allogeneic cell proliferation. This suppressive activity did not correlate with T-cell phenotype. Of the patients with a low number of T-cells, 73% had responded to treatment, whereas of those patients with a normal number of T-cells, 26% had responded (P = 0.016). The results are consistent with abnormal immune response in selected patients with aplastic anemia, and suggest a possible influence of T-cells on disease process.
G J Ruiz-Argüelles, and
J A Katzmann, and
P R Greipp, and
A Marín-López, and
J González-Llaven, and
R Cano-Castellanos
May 1986,
The American journal of the medical sciences,
G J Ruiz-Argüelles, and
J A Katzmann, and
P R Greipp, and
A Marín-López, and
J González-Llaven, and
R Cano-Castellanos
April 1987,
Zhonghua nei ke za zhi,
G J Ruiz-Argüelles, and
J A Katzmann, and
P R Greipp, and
A Marín-López, and
J González-Llaven, and
R Cano-Castellanos
May 1991,
Zhonghua nei ke za zhi,
G J Ruiz-Argüelles, and
J A Katzmann, and
P R Greipp, and
A Marín-López, and
J González-Llaven, and
R Cano-Castellanos
March 1993,
Annals of hematology,
G J Ruiz-Argüelles, and
J A Katzmann, and
P R Greipp, and
A Marín-López, and
J González-Llaven, and
R Cano-Castellanos
January 1984,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
G J Ruiz-Argüelles, and
J A Katzmann, and
P R Greipp, and
A Marín-López, and
J González-Llaven, and
R Cano-Castellanos
September 1984,
British journal of haematology,
G J Ruiz-Argüelles, and
J A Katzmann, and
P R Greipp, and
A Marín-López, and
J González-Llaven, and
R Cano-Castellanos
March 1992,
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine,
G J Ruiz-Argüelles, and
J A Katzmann, and
P R Greipp, and
A Marín-López, and
J González-Llaven, and
R Cano-Castellanos
October 2016,
Zhongguo shi yan xue ye xue za zhi,
G J Ruiz-Argüelles, and
J A Katzmann, and
P R Greipp, and
A Marín-López, and
J González-Llaven, and
R Cano-Castellanos
November 2017,
Life sciences,
G J Ruiz-Argüelles, and
J A Katzmann, and
P R Greipp, and
A Marín-López, and
J González-Llaven, and
R Cano-Castellanos
December 2020,
Hematology (Amsterdam, Netherlands),
