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Lymphocyte subsets have been measured in the blood of 28 patients with aplastic anaemia. The mean helper/inducer:suppressor/cytotoxic T lymphocyte ratio (1.24 +/- 0.74) was significantly decreased in the total population in comparison to mean ratios in a normal population (1.78 +/- 0.57) and in patients with other haematological diseases (1.82 +/- 0.92). A reversed ratio (less than or equal to 1) was present in a large proportion (53%) of aplastic patients, due both to an absolute deficiency of helper/inducer lymphocytes and an increase in suppressor/cytotoxic lymphocytes. Increased HLA-DR expression, evidence of lymphocyte activation, was present in seven of 12 patients evaluated and was confined to the suppressor/cytotoxic lymphocyte population. In the bone marrow, the percentage of lymphocytes was increased two-fold compared to normal bone marrow but the ratio of T cell subsets was not abnormal. Two of four patients evaluated after haematopoietic recovery following ATG treatment showed a return to normal of the T4/T8 ratio; in two others a low T4/T8 ratio persisted despite recovery. These results indicate that lymphocyte subset imbalance and lymphocyte activation are present in many patients with aplastic anaemia, either as a contributing factor or as a result of bone marrow failure.
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N C Zoumbos, and
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N Young
May 1986,
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N C Zoumbos, and
W O Ferris, and
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June 1981,
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N C Zoumbos, and
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March 1993,
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April 1988,
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N C Zoumbos, and
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October 2016,
Zhongguo shi yan xue ye xue za zhi,
N C Zoumbos, and
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January 1987,
Natural immunity and cell growth regulation,
N C Zoumbos, and
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S O Sharrow, and
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A W Nienhuis, and
N Young
April 1987,
Zhonghua nei ke za zhi,
N C Zoumbos, and
W O Ferris, and
S M Hsu, and
S Goodman, and
P Griffith, and
S O Sharrow, and
R K Humphries, and
A W Nienhuis, and
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May 1991,
Zhonghua nei ke za zhi,
N C Zoumbos, and
W O Ferris, and
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S Goodman, and
P Griffith, and
S O Sharrow, and
R K Humphries, and
A W Nienhuis, and
N Young
December 2022,
Annals of medicine,
