-transparent.png){kind=logo}
The comparative effectiveness of vitamin D3 and its derivatives in curing hyperparathyroidism and osteodystrophic bone lesions was examined in a laboratory model of renal osteodystrophy associated with marked secondary hyperparathyroidism in rats. The experimental model was prepared by a single injection of homologous glycopeptide. Plasma levels of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] appeared to decrease in the rats receiving glycopeptide. Various doses of vitamin D3 derivatives [2 or 10 microgram/kg D3, 2 microgram/kg 25-hydroxyvitamin D3 (25OHD3), 0.1 microgram/kg 1 alpha,25(OH)2D3, and 0.1 or 0.2 microgram/kg 1 alpha-hydroxyvitamin D3 (1 alpha OHD3)] were daily administered orally to the nephritic rats for 23 days before sacrifice. 1 alpha,25(OH)2D3 and 1 alpha OHD3 were much more potent than 25OHD3 and D3 in reducing the hyperplasia of parathyroir glands. The potency of 1 alpha OHD3 in curing the histological changes of osteodystrophy appeared to be greater than that of 1 alpha,25(OH)2D3. The same dose level of 1 alpha OHD3 was more effective than 1 alpha,25(OH)2D3 in enhancing plasma 1 alpha,25(OH)2D3 levels.
M Fukushima, and
R Niki, and
H Ohkawa, and
T Shimizu, and
I Matsunaga, and
H Nakano, and
Y Takagaki, and
Y Nishii, and
K Okano, and
T Suda
November 1969,
JAMA,
M Fukushima, and
R Niki, and
H Ohkawa, and
T Shimizu, and
I Matsunaga, and
H Nakano, and
Y Takagaki, and
Y Nishii, and
K Okano, and
T Suda
January 1982,
The Quarterly journal of medicine,
M Fukushima, and
R Niki, and
H Ohkawa, and
T Shimizu, and
I Matsunaga, and
H Nakano, and
Y Takagaki, and
Y Nishii, and
K Okano, and
T Suda
January 1976,
Journal d'urologie et de nephrologie,
M Fukushima, and
R Niki, and
H Ohkawa, and
T Shimizu, and
I Matsunaga, and
H Nakano, and
Y Takagaki, and
Y Nishii, and
K Okano, and
T Suda
June 1978,
The New England journal of medicine,
M Fukushima, and
R Niki, and
H Ohkawa, and
T Shimizu, and
I Matsunaga, and
H Nakano, and
Y Takagaki, and
Y Nishii, and
K Okano, and
T Suda
January 1977,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
M Fukushima, and
R Niki, and
H Ohkawa, and
T Shimizu, and
I Matsunaga, and
H Nakano, and
Y Takagaki, and
Y Nishii, and
K Okano, and
T Suda
January 1998,
Expert opinion on investigational drugs,
M Fukushima, and
R Niki, and
H Ohkawa, and
T Shimizu, and
I Matsunaga, and
H Nakano, and
Y Takagaki, and
Y Nishii, and
K Okano, and
T Suda
December 1978,
Endocrinologia japonica,
M Fukushima, and
R Niki, and
H Ohkawa, and
T Shimizu, and
I Matsunaga, and
H Nakano, and
Y Takagaki, and
Y Nishii, and
K Okano, and
T Suda
January 1987,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
M Fukushima, and
R Niki, and
H Ohkawa, and
T Shimizu, and
I Matsunaga, and
H Nakano, and
Y Takagaki, and
Y Nishii, and
K Okano, and
T Suda
August 1978,
Lancet (London, England),
M Fukushima, and
R Niki, and
H Ohkawa, and
T Shimizu, and
I Matsunaga, and
H Nakano, and
Y Takagaki, and
Y Nishii, and
K Okano, and
T Suda
June 1979,
Endocrinologia japonica,
