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The effects of a bone resorptive protein isolated from human cancer ascites fluid on bone cell calcium and cyclic AMP were studied with fetal rat cells. The osteoclast-activating factor increased bone cell calcium uptake at 37 degrees C and 4 degrees C with no direct effects on calcium efflux. Concentrations of the resorptive factor that increased in vitro bone resorption and cell calcium uptake had no effect on cyclic AMP. The effects of the protein on calcium uptake were not specific for bone cells, and large increases were also observed in isolated fetal rat skin cells. These studies suggest that increases in the permeability of the cell membrane to calcium are involved in the mechanism of action of the ascites fluid resorptive protein.
R Dziak, and
Y W Chang, and
D Humphries, and
W Lloyd, and
H Wells, and
K Schmid, and
R B Nimberg
July 1978,
Cancer research,
R Dziak, and
Y W Chang, and
D Humphries, and
W Lloyd, and
H Wells, and
K Schmid, and
R B Nimberg
August 1979,
Calcified tissue international,
R Dziak, and
Y W Chang, and
D Humphries, and
W Lloyd, and
H Wells, and
K Schmid, and
R B Nimberg
September 1987,
Calcified tissue international,
R Dziak, and
Y W Chang, and
D Humphries, and
W Lloyd, and
H Wells, and
K Schmid, and
R B Nimberg
October 1987,
Cardiovascular research,
R Dziak, and
Y W Chang, and
D Humphries, and
W Lloyd, and
H Wells, and
K Schmid, and
R B Nimberg
June 1986,
FEBS letters,
R Dziak, and
Y W Chang, and
D Humphries, and
W Lloyd, and
H Wells, and
K Schmid, and
R B Nimberg
January 1985,
Archiv fur Geschwulstforschung,
R Dziak, and
Y W Chang, and
D Humphries, and
W Lloyd, and
H Wells, and
K Schmid, and
R B Nimberg
January 1982,
Research communications in chemical pathology and pharmacology,
R Dziak, and
Y W Chang, and
D Humphries, and
W Lloyd, and
H Wells, and
K Schmid, and
R B Nimberg
August 1992,
Annals of allergy,
R Dziak, and
Y W Chang, and
D Humphries, and
W Lloyd, and
H Wells, and
K Schmid, and
R B Nimberg
September 1983,
FEBS letters,
R Dziak, and
Y W Chang, and
D Humphries, and
W Lloyd, and
H Wells, and
K Schmid, and
R B Nimberg
November 1979,
Prostaglandins and medicine,
