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Tumorigenic clonal lines derived from soft agar colonies induced by DMBA-transformed feline embryo cells were isolated and characterized. The morphologically altered clonal cells formed large aggregates, growing in this aggregate form when suspended in liquid growth medium above an agar base and forming colonies in soft agar with high efficiency. When inoculated into athymic nude mice, chemically altered clonal cells produced progressively growing sarcomas. Cells established from the tumors morphologically resembled the DMBA-transformed feline embryo cells and were characterized as cat cells by karyological analysis. The tumorigenic lines were negative for feline oncornavirus-associated cell membrane antigen (FOCMA), and for "gag-X" the transformation-related polyprotein which is encoded by the replication defective feline sarcoma virus.
J S Rhim, and
K S Koh, and
A Chen, and
M Essex
September 1979,
International journal of cancer,
J S Rhim, and
K S Koh, and
A Chen, and
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August 1979,
Science (New York, N.Y.),
J S Rhim, and
K S Koh, and
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December 1979,
Acta neuropathologica,
J S Rhim, and
K S Koh, and
A Chen, and
M Essex
January 1973,
Journal of the National Cancer Institute,
J S Rhim, and
K S Koh, and
A Chen, and
M Essex
May 1981,
Journal of virology,
J S Rhim, and
K S Koh, and
A Chen, and
M Essex
December 1975,
Journal of the National Cancer Institute,
J S Rhim, and
K S Koh, and
A Chen, and
M Essex
August 1981,
In vitro,
J S Rhim, and
K S Koh, and
A Chen, and
M Essex
January 1979,
Acta biologica et medica Germanica,
J S Rhim, and
K S Koh, and
A Chen, and
M Essex
May 1975,
American journal of clinical pathology,
J S Rhim, and
K S Koh, and
A Chen, and
M Essex
April 1976,
Cancer research,
