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Plasma digoxin concentration during maintenance therapy with digoxin was determined in premature and mature newborns, infants, children and adults. The plasma digoxin concentration of newborns was significantly higher than in adults; in addition, in the group of premature newborns it also was higher than in infants and children. These differences in plasma digoxin concentrations may be explained by differences in dose, volume of distribution and excretion rate of digoxin in the various age groups.
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