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Plasma-digoxin and serum creatinine concentrations were determined on admission in 145 unselected patients previously digitalized as outpatients. Adequate digitalization was found in 62.7%, inadequate doses in 15.9% of patients. In the latter group the daily dosage reported by the patients failed to correlate with the plasma-digoxin concentration by radioimmunoassay. One-fifth of all patients had clinical evidence of digitalis intoxication. Of these, 69% had plasma-digoxin concentrations of more than 2.0 ng/ml and 31% less than 2.0 ng/ml. Mean digoxin concentration for all patients with signs of digitalis intoxication was 2.5+/-0.9 ng/ml. In patients simultaneously receiving spironolactone or canrenoate-K+ there was danger of falsely high values for digoxin because of interference of those drugs with the radioimmunoassay.
J Lichey, and
R Schröder, and
N Rietbrock
May 1980,
Wiener klinische Wochenschrift,
J Lichey, and
R Schröder, and
N Rietbrock
March 1978,
Monatsschrift fur Kinderheilkunde,
J Lichey, and
R Schröder, and
N Rietbrock
January 1978,
Klinische Wochenschrift,
J Lichey, and
R Schröder, and
N Rietbrock
July 1974,
British heart journal,
J Lichey, and
R Schröder, and
N Rietbrock
January 1976,
Deutsche medizinische Wochenschrift (1946),
J Lichey, and
R Schröder, and
N Rietbrock
July 1980,
Horumon to rinsho. Clinical endocrinology,
J Lichey, and
R Schröder, and
N Rietbrock
January 1981,
Therapie,
J Lichey, and
R Schröder, and
N Rietbrock
March 1979,
DTW. Deutsche tierarztliche Wochenschrift,
J Lichey, and
R Schröder, and
N Rietbrock
September 1981,
La Nouvelle presse medicale,
J Lichey, and
R Schröder, and
N Rietbrock
March 1979,
Wiener klinische Wochenschrift,
