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The clinical and electrophysiological findings in 2 men who had developed a myasthenic syndrome after taking penicillamine for rheumatoid arthritis will be described. The symptoms began with dysfunction of the eye muscles following a generalised muscle weakness. Course of illness after withdrawal of penicillamine was not uniform. In one of the patients a complete remission occurred within a year. The other became steadily worse and required continuous treatment with cholinesterase inhibitors. Electrophysiological examinations showed neuromuscular blockade, posttetanic exhaustion, posttetanic potentiation was found in one patient only. An immunopharmacological block of acetylcholine receptors induced by penicillamine is discussed from a pathogenetical point of view.
F Schumm, and
M Stöhr
January 1977,
Annales de medecine interne,
F Schumm, and
M Stöhr
January 1978,
Bulletin de la Societe belge d'ophtalmologie,
F Schumm, and
M Stöhr
May 1981,
La Nouvelle presse medicale,
F Schumm, and
M Stöhr
September 1973,
Deutsche medizinische Wochenschrift (1946),
F Schumm, and
M Stöhr
January 1984,
Zeitschrift fur arztliche Fortbildung,
F Schumm, and
M Stöhr
October 1981,
Annals of ophthalmology,
F Schumm, and
M Stöhr
February 1975,
Kokyu to junkan. Respiration & circulation,
F Schumm, and
M Stöhr
December 1981,
Deutsche medizinische Wochenschrift (1946),
F Schumm, and
M Stöhr
October 1975,
Deutsche medizinische Wochenschrift (1946),
F Schumm, and
M Stöhr
December 1974,
Deutsche medizinische Wochenschrift (1946),
