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Relative responses to Rous sarcoma virus (RSV)-induced tumors were studied in UNH 105 chickens, a noninbred line of New Hampshires. A total of 799 chickens blood typed for B alloantigens were classified into six genotypes: B23/B23, B24/B24, B26/B26, B23/B24, B23/B26, and B24/B26. Chickens were inoculated with subgroup A Rous sarcoma virus in the left wingweb at 6 weeks of age. The in vivo response was evaluated and given a tumor profile index (TPI) based on the change in tumor size over a 10-week period postinoculation. The TPI's ranged from 1 (regressor) to 3 (progressor). The mean TPI of B23/B26 hosts (1.7) was significantly smaller than that of all other genotypes studied. The mean TPI's of the homozygous genotypes B23/B23, B26/B26, and B24/B24, were 2.0, 2.3, and 2.9, respectively, and differed significantly in all comparisons. These results suggest complementation of haplotypes influencing the anti-Rous sarcoma response.
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D W Brown, and
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Cancer research,
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W M Collins, and
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Poultry science,
D W Brown, and
W M Collins, and
P H Ward, and
W E Briles
January 1988,
Animal genetics,
D W Brown, and
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P H Ward, and
W E Briles
January 1979,
Folia biologica,
D W Brown, and
W M Collins, and
P H Ward, and
W E Briles
September 2004,
Poultry science,
D W Brown, and
W M Collins, and
P H Ward, and
W E Briles
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Poultry science,
D W Brown, and
W M Collins, and
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Journal of immunology (Baltimore, Md. : 1950),
