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We compared the effects of 500 ml of 0.15M NaCl or 750 ml of 0.15M NaHCO2, infusions on PRA and PAC in 16 normal NaCl-restricted men. More positive sodium balance, greater natriuresis, and lower serum chloride, potassium, and hydrogen ion concentrations were observed after NaHCO3 infusion. PRA decreased (13.8 +/- 1.0 ng/ml angiotensin I per hour to 6.6 +/- 0.70) and PAC did not change (98 +/- 15 ng/dl to 86 +/- 15) after NaCl infusion. Conversely, PRA did not change (9.9 +/- 1.6 to 10.1 +/- 1.6) and PAC decreased (85 +/- 9 to 44 +/- 5) after NaHCO3 infusion. Plasma cortisol declined in both groups. These results suggest that in sodium-restricted man chloride is more important than sodium for the suppression of PRA by NaCl loading and that potassium or hydrogen ion is a more sensitive modulator of aldosterone secretion than is renin.
B A Julian, and
J H Galla, and
G P Guthrie, and
T A Kotchen
February 1983,
The American journal of physiology,
B A Julian, and
J H Galla, and
G P Guthrie, and
T A Kotchen
August 2008,
Ying yong sheng tai xue bao = The journal of applied ecology,
B A Julian, and
J H Galla, and
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T A Kotchen
January 1984,
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B A Julian, and
J H Galla, and
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T A Kotchen
January 1980,
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B A Julian, and
J H Galla, and
G P Guthrie, and
T A Kotchen
July 1979,
The American journal of physiology,
B A Julian, and
J H Galla, and
G P Guthrie, and
T A Kotchen
July 1972,
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B A Julian, and
J H Galla, and
G P Guthrie, and
T A Kotchen
May 1986,
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B A Julian, and
J H Galla, and
G P Guthrie, and
T A Kotchen
January 1982,
The Journal of endocrinology,
B A Julian, and
J H Galla, and
G P Guthrie, and
T A Kotchen
January 1984,
Human physiology,
B A Julian, and
J H Galla, and
G P Guthrie, and
T A Kotchen
December 1995,
Canadian journal of physiology and pharmacology,
