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The ability of four vitamin D analogs to inhibit the liver microsomal vitamin D-25-hydroxylase was determined. 19-Hydroxy-10(S),19-dihydrovitamin D3,25-fluorovitamin D3, 3 beta-hydroxy-9,10-seco-5,7,10(19)-choletrien-24-oic acid dimethylamide and 25-aza-vitamin D3 were competitive inhibitors with apparent KI values of 44, 137, and 870 nM, and 6.4 microM, respectively. The values for the 19-hydroxy-10(S), 19-dihydrovitamin D3, 25-fluorovitamin D3, and 25-aza-vitamin D3 correspond well to other literature reports with respect to their relative in vivo inhibitory properties. 24-Oxovitamin D3 oxime also proved to be a potent inhibitor but a detailed analysis was prohibited by the lack of material. The 3 beta-hydroxy-9,10-seco-5,7,10(19)-choletrien-24-oic acid dimethylamide was also tested in vivo but had no antagonistic activity when provided at a 2000-fold excess over vitamin D3.
B Kabakoff, and
H K Schnoes, and
H F DeLuca
October 1986,
Archives of biochemistry and biophysics,
B Kabakoff, and
H K Schnoes, and
H F DeLuca
November 1988,
Archives of biochemistry and biophysics,
B Kabakoff, and
H K Schnoes, and
H F DeLuca
May 1988,
Journal of biochemistry,
B Kabakoff, and
H K Schnoes, and
H F DeLuca
October 1988,
The Journal of biological chemistry,
B Kabakoff, and
H K Schnoes, and
H F DeLuca
September 1984,
Biochemical and biophysical research communications,
B Kabakoff, and
H K Schnoes, and
H F DeLuca
January 2004,
Molecular genetics and metabolism,
B Kabakoff, and
H K Schnoes, and
H F DeLuca
November 1992,
The Biochemical journal,
B Kabakoff, and
H K Schnoes, and
H F DeLuca
March 1991,
FEBS letters,
B Kabakoff, and
H K Schnoes, and
H F DeLuca
August 2001,
American journal of physiology. Endocrinology and metabolism,
B Kabakoff, and
H K Schnoes, and
H F DeLuca
August 2012,
Poultry science,
