-transparent.png){kind=logo}
Activation of polycyclic aromatic hydrocarbons (PAHs) was examined in the Reuber H4-II-E established cell line without the use of exogenous enzyme preparations. Metabolism of PAHs to genotoxic products was determined by the induction of sister-chromatid exchanges (SCEs). The induction of SCEs followed a dose-response pattern with plateaus at high doses of PAH. The effects of metabolic enzyme inducers (3-methylcholanthrene, phenobarbital, Aroclor 1254) and the epoxide hydrase inhibitor 1,1,1-trichloropropylene oxide were assessed as changes in SCE induction and enhanced production of water-soluble metabolites. Results indicate that Reuber H4-II-E cells can be employed in the testing of carcinogens activated by the P1-450 monooxygenase system and would be a useful in vitro system for the study of mechanisms of metabolic induction and their effect on genetic toxicity.
R G Dean, and
G Bynum, and
D Jacobson-Kram, and
E Hadley
March 1984,
Cancer research,
R G Dean, and
G Bynum, and
D Jacobson-Kram, and
E Hadley
January 1992,
Molecular carcinogenesis,
R G Dean, and
G Bynum, and
D Jacobson-Kram, and
E Hadley
November 1979,
Molecular pharmacology,
R G Dean, and
G Bynum, and
D Jacobson-Kram, and
E Hadley
January 1976,
Journal of cyclic nucleotide research,
R G Dean, and
G Bynum, and
D Jacobson-Kram, and
E Hadley
September 1979,
Biochemical and biophysical research communications,
R G Dean, and
G Bynum, and
D Jacobson-Kram, and
E Hadley
February 1991,
Toxicology,
R G Dean, and
G Bynum, and
D Jacobson-Kram, and
E Hadley
July 1982,
Experientia,
R G Dean, and
G Bynum, and
D Jacobson-Kram, and
E Hadley
December 1995,
Toxicology,
R G Dean, and
G Bynum, and
D Jacobson-Kram, and
E Hadley
January 1978,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
R G Dean, and
G Bynum, and
D Jacobson-Kram, and
E Hadley
July 1967,
Science (New York, N.Y.),
