-transparent.png){kind=logo}
We investigated whether astroglial cells are a site of action for the effect of melatonin on brain cyclic AMP content. Rat astroglial cell subcultures, identified according to morphological and immunochemical criteria, were used. Addition of melatonin to the cultures did not result in changes of cyclic AMP content. However, melatonin at 0.1-1 microM concentrations was able to impair the cyclic AMP increase elicited by 1 microM norepinephrine or isoproterenol in astroglial cultures. This melatonin effect was also shared by its biologically active analogues 5-methoxytryptophol and 6-chloromelatonin. Serotonin was only effective at a 100-fold greater concentration, while the biologically inactive melatonin metabolite 6-hydroxymelatonin was devoid of activity at any concentration used. These results suggest that methoxyindoles modulate negatively beta-adrenoceptor-induced cyclic AMP accumulation in cultured rat astroglial cells.
M I Vacas, and
M I Berría, and
D P Cardinali, and
E F Lascano
December 1989,
Brain research,
M I Vacas, and
M I Berría, and
D P Cardinali, and
E F Lascano
January 1990,
European journal of pharmacology,
M I Vacas, and
M I Berría, and
D P Cardinali, and
E F Lascano
June 1991,
Biochemical pharmacology,
M I Vacas, and
M I Berría, and
D P Cardinali, and
E F Lascano
July 1994,
Journal of neurochemistry,
M I Vacas, and
M I Berría, and
D P Cardinali, and
E F Lascano
June 1987,
FEBS letters,
M I Vacas, and
M I Berría, and
D P Cardinali, and
E F Lascano
April 1992,
Epithelial cell biology,
M I Vacas, and
M I Berría, and
D P Cardinali, and
E F Lascano
February 1985,
Japanese journal of pharmacology,
M I Vacas, and
M I Berría, and
D P Cardinali, and
E F Lascano
November 1990,
Biochemical pharmacology,
M I Vacas, and
M I Berría, and
D P Cardinali, and
E F Lascano
January 1988,
Life sciences,
M I Vacas, and
M I Berría, and
D P Cardinali, and
E F Lascano
May 1997,
Biochemical pharmacology,
