-transparent.png){kind=logo}
Patients with resistant or recurrent acute lymphoblastic leukemia were treated with vindesine 3 mg/m2/IV weekly X 4, daunomycin 25 mg/m2/IV weekly X 4, and prednisone 40 mg/m2/PO daily X 28. Seventeen (44%) of 38 evaluable patients achieved complete remission. Fifty-one percent of 31 patients in first relapse achieved complete remission, while only one of five in second or third relapse and neither of two resistant to first induction achieved complete remission. The major toxicity was hematologic. The median duration of complete remission was only 6 weeks and median survival from start of the study, 3 months, with 22% patients remaining alive at 10 months. We conclude that the vindesine, prednisone, and daunomycin combination is no more effective than vincristine, prednisone, and daunomycin in achieving remission of relapsed acute lymphoblastic leukemia patients, and is more toxic than the latter regimen.
G Garay, and
J Milone, and
E Dibar, and
S Pavlovsky, and
R Kvicala, and
F Sackmann Muriel, and
D Montres Varela, and
M Eppinger-Helft
March 1971,
Cancer,
G Garay, and
J Milone, and
E Dibar, and
S Pavlovsky, and
R Kvicala, and
F Sackmann Muriel, and
D Montres Varela, and
M Eppinger-Helft
August 1992,
Investigational new drugs,
G Garay, and
J Milone, and
E Dibar, and
S Pavlovsky, and
R Kvicala, and
F Sackmann Muriel, and
D Montres Varela, and
M Eppinger-Helft
May 1983,
Cancer treatment reports,
G Garay, and
J Milone, and
E Dibar, and
S Pavlovsky, and
R Kvicala, and
F Sackmann Muriel, and
D Montres Varela, and
M Eppinger-Helft
May 1983,
Cancer treatment reports,
G Garay, and
J Milone, and
E Dibar, and
S Pavlovsky, and
R Kvicala, and
F Sackmann Muriel, and
D Montres Varela, and
M Eppinger-Helft
January 2014,
Chinese medical journal,
G Garay, and
J Milone, and
E Dibar, and
S Pavlovsky, and
R Kvicala, and
F Sackmann Muriel, and
D Montres Varela, and
M Eppinger-Helft
June 2004,
Indian journal of pediatrics,
G Garay, and
J Milone, and
E Dibar, and
S Pavlovsky, and
R Kvicala, and
F Sackmann Muriel, and
D Montres Varela, and
M Eppinger-Helft
June 1981,
Cancer,
G Garay, and
J Milone, and
E Dibar, and
S Pavlovsky, and
R Kvicala, and
F Sackmann Muriel, and
D Montres Varela, and
M Eppinger-Helft
January 1977,
Oncology,
G Garay, and
J Milone, and
E Dibar, and
S Pavlovsky, and
R Kvicala, and
F Sackmann Muriel, and
D Montres Varela, and
M Eppinger-Helft
September 2023,
Urology case reports,
G Garay, and
J Milone, and
E Dibar, and
S Pavlovsky, and
R Kvicala, and
F Sackmann Muriel, and
D Montres Varela, and
M Eppinger-Helft
January 2002,
Bulletin de la Societe belge d'ophtalmologie,
