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Patients with recurrent acute lymphoblastic leukemia were treated with daunorubicin (40 mg/m2/week X 4), vincristine (1.5 mg/m2/week X 4), and prednisone (40 mg/m2/day x 28). All of the patients had been treated with the same combination during the first induction treatment. Of 266 patients (221 children and 45 adults) treated in first relapse, 141 (53%) achieved complete remission (CR; 55% of the children and 44% of the adults). Of 61 patients who were re-treated with the same combination after the second relapse, 14 (23%) achieved CR. The difference between second and third CR was statistically significant (P less than 0.0005). The median durations of second and third CR were 8 and 6 weeks, respectively. No significant difference was observed when the duration of CR was compared with the initial wbc count, age at diagnosis, or duration of first CR.
S Pavlovsky, and
F S Muriel, and
M Eppinger-Helft, and
P Bustelo, and
G Garay, and
J M Giuntoli, and
R Kvicala, and
J Divito, and
A Picón
February 1995,
Annals of hematology,
S Pavlovsky, and
F S Muriel, and
M Eppinger-Helft, and
P Bustelo, and
G Garay, and
J M Giuntoli, and
R Kvicala, and
J Divito, and
A Picón
February 1978,
Cancer,
S Pavlovsky, and
F S Muriel, and
M Eppinger-Helft, and
P Bustelo, and
G Garay, and
J M Giuntoli, and
R Kvicala, and
J Divito, and
A Picón
January 1977,
Oncology,
S Pavlovsky, and
F S Muriel, and
M Eppinger-Helft, and
P Bustelo, and
G Garay, and
J M Giuntoli, and
R Kvicala, and
J Divito, and
A Picón
April 1973,
Cancer,
S Pavlovsky, and
F S Muriel, and
M Eppinger-Helft, and
P Bustelo, and
G Garay, and
J M Giuntoli, and
R Kvicala, and
J Divito, and
A Picón
January 1979,
Medical and pediatric oncology,
S Pavlovsky, and
F S Muriel, and
M Eppinger-Helft, and
P Bustelo, and
G Garay, and
J M Giuntoli, and
R Kvicala, and
J Divito, and
A Picón
January 1976,
Medical and pediatric oncology,
S Pavlovsky, and
F S Muriel, and
M Eppinger-Helft, and
P Bustelo, and
G Garay, and
J M Giuntoli, and
R Kvicala, and
J Divito, and
A Picón
April 2000,
Cancer,
S Pavlovsky, and
F S Muriel, and
M Eppinger-Helft, and
P Bustelo, and
G Garay, and
J M Giuntoli, and
R Kvicala, and
J Divito, and
A Picón
February 1977,
Cancer research,
S Pavlovsky, and
F S Muriel, and
M Eppinger-Helft, and
P Bustelo, and
G Garay, and
J M Giuntoli, and
R Kvicala, and
J Divito, and
A Picón
November 1978,
Archives of internal medicine,
S Pavlovsky, and
F S Muriel, and
M Eppinger-Helft, and
P Bustelo, and
G Garay, and
J M Giuntoli, and
R Kvicala, and
J Divito, and
A Picón
January 1984,
Sangre,
