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Plasma concentrations of thromboxane and prostaglandin I2 (PGI2) before and after IV injection of endotoxin and resulting hemodynamic changes were evaluated. Effects of flunixin meglumine on plasma concentrations of these prostaglandins and the related hemodynamic changes were also determined. Shock was induced in 2 groups of anesthetized dogs. Four dogs were given endotoxin only and 4 dogs were given endotoxin and then were treated with flunixin meglumine. Arterial blood pressure (BP), cardiac output (CO), and heart rate were measured, and blood samples were collected at postendotoxin hours (PEH) 0, 0.1, 0.25, 0.5, 1, 2, 3, and 4. Plasma thromboxane and PGI2 concentrations were increased in canine endotoxic shock. Thromboxane concentration was highest early in shock, and appeared to be associated with an initial decrease in BP and CO. The increased concentration of PGI2 was associated with systemic hypotension at PEH 1 to 2. Treatment of dogs with flunixin meglumine at PEH 0.07 prevented further increase of thromboxane and blocked the release of PGI2, resulting in an increased CO, BP, and tissue aerobic metabolism.
G D Bottoms, and
M A Johnson, and
O F Roesel
January 1981,
Stroke,
G D Bottoms, and
M A Johnson, and
O F Roesel
August 1981,
The Journal of clinical investigation,
G D Bottoms, and
M A Johnson, and
O F Roesel
May 1992,
Arerugi = [Allergy],
G D Bottoms, and
M A Johnson, and
O F Roesel
June 1986,
Changgeng yi xue za zhi,
G D Bottoms, and
M A Johnson, and
O F Roesel
June 1989,
Nihon Jinzo Gakkai shi,
G D Bottoms, and
M A Johnson, and
O F Roesel
November 1994,
Archives of oral biology,
G D Bottoms, and
M A Johnson, and
O F Roesel
March 1983,
Nihon Sanka Fujinka Gakkai zasshi,
G D Bottoms, and
M A Johnson, and
O F Roesel
March 1981,
Fukuoka igaku zasshi = Hukuoka acta medica,
G D Bottoms, and
M A Johnson, and
O F Roesel
August 1987,
Prostaglandins, leukotrienes, and medicine,
G D Bottoms, and
M A Johnson, and
O F Roesel
February 1975,
The American journal of physiology,
