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Two cases of gastrin releasing peptide (GRP)-producing medullary thyroid carcinoma are presented. Immunohistochemical examination revealed the presence of GRP-like immunoreactivity (IR-GRP) in the primary tumor tissues. High concentration of IR-GRP was also demonstrated in extracts of the primary tumors by radioimmunologic means with use of a GRP-specific antiserum. Chromatographic analysis showed that the immunoreactivity was composed of at least two molecular forms: one behaved as synthetic porcine GRP on Sephadex G-50 gel filtration and the other as porcine GRP (14-27), a C-terminal active fragment of GRP. The IR-GRP was shown not to be attributed to bombesin-like immunoreactivity. Substance P-like immunoreactivity was not detected in the tumor tissues by either immunohistochemical or radioimmunologic means. This is, as far as the authors are aware, the first finding of IR-GRP as an ectopic product in medullary carcinoma.
S Matsubayashi, and
C Yanaihara, and
M Ohkubo, and
S Fukata, and
Y Hayashi, and
H Tamai, and
T Nakagawa, and
A Miyauchi, and
K Kuma, and
K Abe
November 1985,
American journal of clinical pathology,
S Matsubayashi, and
C Yanaihara, and
M Ohkubo, and
S Fukata, and
Y Hayashi, and
H Tamai, and
T Nakagawa, and
A Miyauchi, and
K Kuma, and
K Abe
October 1990,
The Journal of clinical endocrinology and metabolism,
S Matsubayashi, and
C Yanaihara, and
M Ohkubo, and
S Fukata, and
Y Hayashi, and
H Tamai, and
T Nakagawa, and
A Miyauchi, and
K Kuma, and
K Abe
August 2021,
Clinical chemistry and laboratory medicine,
S Matsubayashi, and
C Yanaihara, and
M Ohkubo, and
S Fukata, and
Y Hayashi, and
H Tamai, and
T Nakagawa, and
A Miyauchi, and
K Kuma, and
K Abe
February 1990,
Surgery,
S Matsubayashi, and
C Yanaihara, and
M Ohkubo, and
S Fukata, and
Y Hayashi, and
H Tamai, and
T Nakagawa, and
A Miyauchi, and
K Kuma, and
K Abe
August 2000,
Oncology,
S Matsubayashi, and
C Yanaihara, and
M Ohkubo, and
S Fukata, and
Y Hayashi, and
H Tamai, and
T Nakagawa, and
A Miyauchi, and
K Kuma, and
K Abe
January 1983,
Virchows Archiv. A, Pathological anatomy and histopathology,
S Matsubayashi, and
C Yanaihara, and
M Ohkubo, and
S Fukata, and
Y Hayashi, and
H Tamai, and
T Nakagawa, and
A Miyauchi, and
K Kuma, and
K Abe
August 1984,
Metabolism: clinical and experimental,
S Matsubayashi, and
C Yanaihara, and
M Ohkubo, and
S Fukata, and
Y Hayashi, and
H Tamai, and
T Nakagawa, and
A Miyauchi, and
K Kuma, and
K Abe
October 1984,
American journal of clinical pathology,
S Matsubayashi, and
C Yanaihara, and
M Ohkubo, and
S Fukata, and
Y Hayashi, and
H Tamai, and
T Nakagawa, and
A Miyauchi, and
K Kuma, and
K Abe
May 1988,
Cancer research,
S Matsubayashi, and
C Yanaihara, and
M Ohkubo, and
S Fukata, and
Y Hayashi, and
H Tamai, and
T Nakagawa, and
A Miyauchi, and
K Kuma, and
K Abe
November 2001,
Thyroid : official journal of the American Thyroid Association,
