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Human neuroendocrine tumors are known to demonstrate immunoreactivity to the amphibian peptide bombesin. The recent observation that gastrin-releasing peptide (GRP), a 27 amino acid peptide first isolated from porcine intestine, may be the mammalian analog of bombesin led us to look for this peptide in intestinal carcinoid tumors. Formalin-fixed tissues from 20 of these tumors were examined by the immunoperoxidase technic, using specific antisera to the GRP molecule (1-27) and the GRP fragment (1-16). Intense diffuse cytoplasmic immunoreactivity was observed in carcinoids from the small intestine (7/10), appendix (4/5), and colon (1/5). In each positive case, the pattern of staining for GRP (1-16) and GRP (1-27) was identical. These findings indicate that bombesin-like immunoreactivity in human intestinal carcinoid tumors is attributable to GRP-like molecules and that GRP is a useful marker for neuroendocrine differentiation.
D G Bostwick, and
K A Roth, and
J D Barchas, and
K G Bensch
June 1984,
Cancer,
D G Bostwick, and
K A Roth, and
J D Barchas, and
K G Bensch
November 1985,
American journal of clinical pathology,
D G Bostwick, and
K A Roth, and
J D Barchas, and
K G Bensch
December 1989,
Surgery,
D G Bostwick, and
K A Roth, and
J D Barchas, and
K G Bensch
July 1993,
Pancreas,
D G Bostwick, and
K A Roth, and
J D Barchas, and
K G Bensch
July 1989,
International journal of peptide and protein research,
D G Bostwick, and
K A Roth, and
J D Barchas, and
K G Bensch
April 1987,
Gastroenterologia Japonica,
D G Bostwick, and
K A Roth, and
J D Barchas, and
K G Bensch
September 1989,
Molecular and cellular endocrinology,
D G Bostwick, and
K A Roth, and
J D Barchas, and
K G Bensch
September 1985,
European journal of pharmacology,
D G Bostwick, and
K A Roth, and
J D Barchas, and
K G Bensch
January 1994,
Peptides,
D G Bostwick, and
K A Roth, and
J D Barchas, and
K G Bensch
February 2004,
Journal of clinical pathology,
