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It has been recently reported that cord blood lymphocytes (CBL) contain a subpopulation of OKT8+, sheep erythrocyte-rosetting negative (E-) cells not detectable in adult peripheral blood lymphocytes (a-PBL). The present studies were undertaken to characterize this subset of lymphocytes functionally and phenotypically. OKT8+ cells were purified from E-depleted CBL by negative selection on nylon-wool columns as well as by positive selection on plates coated with rabbit antibody to murine IgG (panning). The purified CBL displayed natural killer (NK) activity against K562 erythroleukemic cells. Although most of these CBL were large granular lymphocytes, they lacked typical NK markers such as HNK-1 and OKM1 surface antigens. Most OKT8+, OKT3- cells were also OKT10+, Ia+ and had the receptor for peanut agglutinin. These CBL may represent a stage along the differentiation pathway leading to mature NK or T cells.
A Vitiello, and
R Maccario, and
D Montagna, and
F A Porta, and
C M Alberini, and
G Mingrat, and
G C Astaldi-Ricotti, and
L Nespoli, and
A G Ugazio
January 1986,
Thymus,
A Vitiello, and
R Maccario, and
D Montagna, and
F A Porta, and
C M Alberini, and
G Mingrat, and
G C Astaldi-Ricotti, and
L Nespoli, and
A G Ugazio
August 1993,
British journal of anaesthesia,
A Vitiello, and
R Maccario, and
D Montagna, and
F A Porta, and
C M Alberini, and
G Mingrat, and
G C Astaldi-Ricotti, and
L Nespoli, and
A G Ugazio
March 1987,
Clinical and experimental immunology,
A Vitiello, and
R Maccario, and
D Montagna, and
F A Porta, and
C M Alberini, and
G Mingrat, and
G C Astaldi-Ricotti, and
L Nespoli, and
A G Ugazio
September 1984,
Scandinavian journal of immunology,
A Vitiello, and
R Maccario, and
D Montagna, and
F A Porta, and
C M Alberini, and
G Mingrat, and
G C Astaldi-Ricotti, and
L Nespoli, and
A G Ugazio
November 1982,
Cellular immunology,
A Vitiello, and
R Maccario, and
D Montagna, and
F A Porta, and
C M Alberini, and
G Mingrat, and
G C Astaldi-Ricotti, and
L Nespoli, and
A G Ugazio
October 1981,
Clinical immunology and immunopathology,
A Vitiello, and
R Maccario, and
D Montagna, and
F A Porta, and
C M Alberini, and
G Mingrat, and
G C Astaldi-Ricotti, and
L Nespoli, and
A G Ugazio
April 1991,
Acta endocrinologica,
A Vitiello, and
R Maccario, and
D Montagna, and
F A Porta, and
C M Alberini, and
G Mingrat, and
G C Astaldi-Ricotti, and
L Nespoli, and
A G Ugazio
July 1986,
The Journal of experimental medicine,
A Vitiello, and
R Maccario, and
D Montagna, and
F A Porta, and
C M Alberini, and
G Mingrat, and
G C Astaldi-Ricotti, and
L Nespoli, and
A G Ugazio
April 1986,
Immunological investigations,
A Vitiello, and
R Maccario, and
D Montagna, and
F A Porta, and
C M Alberini, and
G Mingrat, and
G C Astaldi-Ricotti, and
L Nespoli, and
A G Ugazio
October 1988,
The Journal of investigative dermatology,
