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A GLC-mass fragmentographic method was developed for the simultaneous determination of mannitol and sorbitol as their n-butyldiboronate derivatives in plasma. The plasma sample was deproteinized, and the subsequent supernatant was concentrated to dryness; the resulting residue was then dissolved in pyridine containing n-butylboronic acid to allow derivation. An aliquot of this solution was injected into the gas chromatograph-mass spectrometer and analyzed by a selected-ion monitoring method using galactitol as the internal standard. Detection was limited to 20 ng/0.1 ml of plasma for both mannitol and sorbitol. A rapid, precise, and sensitive assay for the determination of mannitol and sorbitol in plasma was established.
T Marunaka, and
E Matsushima, and
Y Umeno, and
Y Minami
November 1972,
Journal of pharmaceutical sciences,
T Marunaka, and
E Matsushima, and
Y Umeno, and
Y Minami
August 1981,
Journal of pharmaceutical sciences,
T Marunaka, and
E Matsushima, and
Y Umeno, and
Y Minami
January 1975,
Journal of pharmaceutical sciences,
T Marunaka, and
E Matsushima, and
Y Umeno, and
Y Minami
September 1977,
Journal of pharmaceutical sciences,
T Marunaka, and
E Matsushima, and
Y Umeno, and
Y Minami
January 1977,
Acta pharmaceutica Suecica,
T Marunaka, and
E Matsushima, and
Y Umeno, and
Y Minami
March 1970,
Annales pharmaceutiques francaises,
T Marunaka, and
E Matsushima, and
Y Umeno, and
Y Minami
May 1981,
Journal of pharmaceutical sciences,
T Marunaka, and
E Matsushima, and
Y Umeno, and
Y Minami
January 1972,
Journal of pharmaceutical sciences,
T Marunaka, and
E Matsushima, and
Y Umeno, and
Y Minami
October 1974,
Biomedical mass spectrometry,
T Marunaka, and
E Matsushima, and
Y Umeno, and
Y Minami
October 1975,
Journal of chromatography,
