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Pancreatic islet B cells express class I but not class II antigens, and removal of Ia positive passenger cells from H-2 allogeneic islets by anti-Ia serum and complement leads to permanent allograft survival. A test was made of whether the same result can be achieved by genetically removing the Ia stimulus by performing mouse islet allografts in congenic donor-recipient combinations differing at the H-2 K only, D only, or K + D regions. Mice disparate for class I antigens (H-2 K, D, and K + D) alone reject islet allografts, suggesting that Ia positive passenger cells may be involved in presentation of class I disparities. Established islet allografts appear to be sensitive to rejection induced by injection of donor strain splenocytes when donor and recipient differ for class I (H-2 D alone and D + I) but not class II (H-2 I alone) antigens. These results are consistent with the hypothesis that pancreatic islet allografts do not express class II target antigens, but do express class I antigens that in long-established pancreatic islet allografts are capable of acting as targets but not in initiating an immune response.
C E Morrow, and
D E Sutherland, and
M W Steffes, and
D Kaufman, and
J S Najarian, and
F H Bach
April 1992,
Transplantation,
C E Morrow, and
D E Sutherland, and
M W Steffes, and
D Kaufman, and
J S Najarian, and
F H Bach
May 1999,
Transplantation,
C E Morrow, and
D E Sutherland, and
M W Steffes, and
D Kaufman, and
J S Najarian, and
F H Bach
August 1986,
Transplantation,
C E Morrow, and
D E Sutherland, and
M W Steffes, and
D Kaufman, and
J S Najarian, and
F H Bach
February 1993,
Transplantation proceedings,
C E Morrow, and
D E Sutherland, and
M W Steffes, and
D Kaufman, and
J S Najarian, and
F H Bach
February 1987,
Transplantation proceedings,
C E Morrow, and
D E Sutherland, and
M W Steffes, and
D Kaufman, and
J S Najarian, and
F H Bach
December 1995,
Transplantation proceedings,
C E Morrow, and
D E Sutherland, and
M W Steffes, and
D Kaufman, and
J S Najarian, and
F H Bach
February 1987,
Diabetologia,
C E Morrow, and
D E Sutherland, and
M W Steffes, and
D Kaufman, and
J S Najarian, and
F H Bach
August 2012,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
C E Morrow, and
D E Sutherland, and
M W Steffes, and
D Kaufman, and
J S Najarian, and
F H Bach
May 1998,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
C E Morrow, and
D E Sutherland, and
M W Steffes, and
D Kaufman, and
J S Najarian, and
F H Bach
September 1993,
European journal of immunology,
