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The basal and TRH-induced prolactin (PRL) and TSH secretions were examined in 14 children aged 4 to 13 years with newly diagnosed insulin dependent diabetes (IDD) within three weeks after diagnosis. Basal PRL levels did not differ from the values of control. In response to TRH, 6 out of 14 patients showed an exaggerated PRL response and 8 a normal PRL response. The basal and TRH-induced TSH secretions were normal, while plasma triiodothyronine (T3) and thyroxine (T4) concentrations were significantly (p less than 0.001, p less than 0.02) lower in patients than in controls. These findings suggest that a significant proportion of children with newly diagnosed IDD has an exaggerated PRL response to TRH, and TSH secretion remains unchanged despite significant decreases of circulating thyroid hormone levels.
K Abe, and
N Matsuura, and
N Fukushima, and
Y Nohara, and
H Fujita, and
K Fujieda, and
T Kato
June 1985,
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K Abe, and
N Matsuura, and
N Fukushima, and
Y Nohara, and
H Fujita, and
K Fujieda, and
T Kato
May 1992,
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K Abe, and
N Matsuura, and
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K Fujieda, and
T Kato
May 1978,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
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K Fujieda, and
T Kato
June 1973,
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March 1968,
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T Kato
September 1992,
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K Abe, and
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N Fukushima, and
Y Nohara, and
H Fujita, and
K Fujieda, and
T Kato
May 1981,
The Journal of clinical endocrinology and metabolism,
K Abe, and
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H Fujita, and
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January 1978,
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K Abe, and
N Matsuura, and
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Y Nohara, and
H Fujita, and
K Fujieda, and
T Kato
April 1985,
The Journal of clinical endocrinology and metabolism,
