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The effect of TRH on GH secretion was assessed in 13 insulin-dependent diabetics. PRL and TSH responses to TRH were also determined. Glycosylated hemoglobin levels and serial fasting glucose concentrations indicated that all but 1 of the patients had a period of poor diabetic control for several months before the study. Peak PRL and TSH levels after TRH injection in these diabetic patients did not differ significantly from values observed in nondiabetic individuals. Six of the patients responded to TRH with a significant rise in GH levels; basal GH concentrations were also elevated in these patients. Five of the 6 responders and none of the nonresponders had proliferative diabetic retinopathy. The results suggest that diabetics with elevated basal GH levels hyperrespond to TRH, and that nonspecific secretion of GH in response to TRH occurs in some patients with proliferative diabetic retinopathy. Chronic hyperglycemia does not appear to be the critical factor in determining this response.
A Dasmahapatra, and
E Urdanivia, and
M P Cohen
August 1984,
Endocrinologia japonica,
A Dasmahapatra, and
E Urdanivia, and
M P Cohen
August 1980,
Endocrinologia japonica,
A Dasmahapatra, and
E Urdanivia, and
M P Cohen
February 1979,
Endocrinologia japonica,
A Dasmahapatra, and
E Urdanivia, and
M P Cohen
January 1978,
Biology of the neonate,
A Dasmahapatra, and
E Urdanivia, and
M P Cohen
January 1980,
Neuropsychobiology,
A Dasmahapatra, and
E Urdanivia, and
M P Cohen
June 1982,
The Journal of clinical endocrinology and metabolism,
A Dasmahapatra, and
E Urdanivia, and
M P Cohen
June 1986,
Biological psychiatry,
A Dasmahapatra, and
E Urdanivia, and
M P Cohen
August 1985,
Zhonghua yi xue za zhi,
A Dasmahapatra, and
E Urdanivia, and
M P Cohen
January 1984,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A Dasmahapatra, and
E Urdanivia, and
M P Cohen
January 1990,
Acta diabetologica latina,
