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In this communication we describe the rapid increase in cellular deoxynucleoside triphosphate (dNTP) concentrations in Chinese Hamster cell line V79 after exposure to known mutagens. With this cell line an expansion of dATP and dTTP pools was detected; changes in dCTP were not large; changes in dGTP were either not significant or too low to quantitate. This situation may reflect the existence of imbalances in dNTP pools at the DNA replication fork. The expansion of dATP and dTTP pools occurred within 2 to 4 hours after exposure of cultured cells to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Ultraviolet light (UV), mitomycin C, and cytosine arabinoside also caused similar dNTP pool changes.
S K Das, and
E P Benditt, and
L A Loeb
January 1988,
Mutation research,
S K Das, and
E P Benditt, and
L A Loeb
January 1985,
Pharmacology & therapeutics,
S K Das, and
E P Benditt, and
L A Loeb
January 1984,
Mutation research,
S K Das, and
E P Benditt, and
L A Loeb
January 2018,
Biology methods & protocols,
S K Das, and
E P Benditt, and
L A Loeb
September 1972,
The Biochemical journal,
S K Das, and
E P Benditt, and
L A Loeb
January 1989,
Advances in experimental medicine and biology,
S K Das, and
E P Benditt, and
L A Loeb
December 2022,
Cell metabolism,
S K Das, and
E P Benditt, and
L A Loeb
November 1983,
Biochemical and biophysical research communications,
S K Das, and
E P Benditt, and
L A Loeb
March 1983,
Proceedings of the National Academy of Sciences of the United States of America,
S K Das, and
E P Benditt, and
L A Loeb
January 1981,
Somatic cell genetics,
