-transparent.png){kind=logo}
In a study of 277 patients with breast carcinomas, the PAP immunoperoxidase method for demonstrating endogenous estrogen was correlated with the sucrose density gradient (SDG) assay and with histologic and clinical features. The results from the PAP method and SDG assay agreed in 59 of 84 patients (82.1%) on whom both methods were performed. Histologically, the PAP method was positive in 7 of 7 patients with non-invasive carcinomas, in 164 of 233 patients (70.4%) with common invasive ductal carcinoma, and in 21 of 22 of those with special histological types of of invasive carcinomas not including Paget's disease, medullary or apocrine carcinoma, where only 5 of 14 were positive. Clinically, 15 of 18 patients with positive endogenous estrogen showed a response to endocrine therapy as opposed to 1 of 9 patients with a negative endogenous estrogen. The mean survival was 31.2 and 15.6 months, respectively for patients with positive and negative endogenous estrogen. Remission for longer than 2 years was seen more often in patients with positive endogenous estrogen. These results suggest a clinical utility of the present PAP method which, therefore, deserves a further trial as an alternative to histochemical methods aiming at the estrogen receptors.
I Katayama, and
M Shimizu, and
M Miura, and
M Maruyama, and
M Kobayashi, and
Y Iino, and
M Izuo, and
S Wakatsuki
November 1981,
Ugeskrift for laeger,
I Katayama, and
M Shimizu, and
M Miura, and
M Maruyama, and
M Kobayashi, and
Y Iino, and
M Izuo, and
S Wakatsuki
January 1982,
Virchows Archiv. B, Cell pathology including molecular pathology,
I Katayama, and
M Shimizu, and
M Miura, and
M Maruyama, and
M Kobayashi, and
Y Iino, and
M Izuo, and
S Wakatsuki
April 1994,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
I Katayama, and
M Shimizu, and
M Miura, and
M Maruyama, and
M Kobayashi, and
Y Iino, and
M Izuo, and
S Wakatsuki
January 1987,
Pathologica,
I Katayama, and
M Shimizu, and
M Miura, and
M Maruyama, and
M Kobayashi, and
Y Iino, and
M Izuo, and
S Wakatsuki
February 1981,
Gan,
I Katayama, and
M Shimizu, and
M Miura, and
M Maruyama, and
M Kobayashi, and
Y Iino, and
M Izuo, and
S Wakatsuki
January 1982,
Acta cytologica,
I Katayama, and
M Shimizu, and
M Miura, and
M Maruyama, and
M Kobayashi, and
Y Iino, and
M Izuo, and
S Wakatsuki
April 1985,
Onkologie,
I Katayama, and
M Shimizu, and
M Miura, and
M Maruyama, and
M Kobayashi, and
Y Iino, and
M Izuo, and
S Wakatsuki
January 1987,
Pathologica,
I Katayama, and
M Shimizu, and
M Miura, and
M Maruyama, and
M Kobayashi, and
Y Iino, and
M Izuo, and
S Wakatsuki
December 1980,
Cancer,
I Katayama, and
M Shimizu, and
M Miura, and
M Maruyama, and
M Kobayashi, and
Y Iino, and
M Izuo, and
S Wakatsuki
May 1982,
European journal of cancer & clinical oncology,
