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The cytochrome P-450 content promptly fell in adult rat hepatocytes cultured in conventional conditions whereas no obvious change was detected over a 10-day period when these cells were co-cultured with another rat liver epithelial cell type. A concomitant maintenance of the amino-pyrine N-demethylase activity and a high aflatoxin B1-induced cytotoxicity was observed, and addition of phenobarbital to the culture medium produced about a 2-fold increase in cytochrome P-450 level. These results indicate that when placed in co-culture, adult hepatocytes remain differentiated for several days and suggest that such a co-culture system is an appropriate model for pharmacotoxicological studies.
J M Begue, and
C Guguen-Guillouzo, and
N Pasdeloup, and
A Guillouzo
January 1983,
Experimental cell research,
J M Begue, and
C Guguen-Guillouzo, and
N Pasdeloup, and
A Guillouzo
May 1985,
Archives of biochemistry and biophysics,
J M Begue, and
C Guguen-Guillouzo, and
N Pasdeloup, and
A Guillouzo
December 1980,
Biochimica et biophysica acta,
J M Begue, and
C Guguen-Guillouzo, and
N Pasdeloup, and
A Guillouzo
April 1984,
Biochemical and biophysical research communications,
J M Begue, and
C Guguen-Guillouzo, and
N Pasdeloup, and
A Guillouzo
March 1999,
Drug metabolism and disposition: the biological fate of chemicals,
J M Begue, and
C Guguen-Guillouzo, and
N Pasdeloup, and
A Guillouzo
October 1979,
Life sciences,
J M Begue, and
C Guguen-Guillouzo, and
N Pasdeloup, and
A Guillouzo
March 1982,
Biochemical pharmacology,
J M Begue, and
C Guguen-Guillouzo, and
N Pasdeloup, and
A Guillouzo
July 1990,
European journal of biochemistry,
J M Begue, and
C Guguen-Guillouzo, and
N Pasdeloup, and
A Guillouzo
March 1995,
The international journal of biochemistry & cell biology,
J M Begue, and
C Guguen-Guillouzo, and
N Pasdeloup, and
A Guillouzo
January 1985,
Hepatology (Baltimore, Md.),
