Biomaterial Database

[Treatment of endometriosis, Clinical trial with danazol]. 1981

H H Senft, and F A Schröder, and W Korte

21 women with endometriosis were treated with Danazol, a derivative of 17-alpha-aethinyltestosteron in an open study over a period of 6 months. 20 women had previously undergone an operation because of the spread of endometriosis and its symptoms, in no case was it possible to remove the source of the endometriosis entirely. Histological confirmation of the endometriosis was ensured in each case. The initial dose was 600 mg Danazol daily. In 17 cases the dose was reduced in the course of 6 months and in 5 cases treatment had to be stopped between the 4th and 6th month. An improvement of the symptoms arising occurred under this treatment. Side-effects, observed during the treatment with Danazol, such as acne vulgaris, seborrhoea, flushes and headaches occurred in 6 respectively 5 cases (28,6 respectively 23,8%). Very occasionally pain in the joints was reported. Almost all women put on weight. The effect of this treatment on fat- and glycometabolism, on liver- and kidney function, on blood-coagulation as well as bloodpressure was examined, no divergence from the norm was observed.

UI	MeSH Term	Description	Entries
D007044	Hysterectomy	Excision of the uterus.	Hysterectomies
D007592	Joint Diseases	Diseases involving the JOINTS.	Arthropathies,Arthropathy,Joint Disease
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010146	Pain	An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D011245	Pregnadienes	Pregnane derivatives containing two double bonds anywhere within the ring structures.
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D001941	Breast Diseases	Pathological processes of the BREAST.	Endocrine Breast Diseases,Breast Disease,Breast Disease, Endocrine,Breast Diseases, Endocrine,Disease, Breast,Disease, Endocrine Breast,Diseases, Breast,Diseases, Endocrine Breast,Endocrine Breast Disease
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D003613	Danazol	A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.	Azol,Cyclomen,Danatrol,Danazant,Danazol-Ratiopharm,Danocrine,Danol,Danoval,Ladogal,Norciden,Panacrine,Danazol Ratiopharm
D004414	Dyspareunia	Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.