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The effects of subchronic desferrioxamine (DFO) infusion on aluminum (A1) loaded rabbits were studied. Rabbits received sc injections of A1 lactate (600 mumoles A1/kg) or Na lactate (1800 mumoles/kg) 5 days per week for 4 weeks. Beginning 2 weeks later rabbits received DFO by sc infusion at a rate of 3.85 mg/hour for 4 weeks (total dose = 2550 mg), or sham treatment. The treatment groups were: control, DFO-only, A1-only, and A1+DFO. A1-induced reductions in food consumption and efficiency of food utilization were not affected by DFO. A1-induced decreases in water consumption were enhanced by DFO. A1 levels were reduced in 10 of 12 organs and brain regions of A1+DFO vs. A1-only groups, but results were statistically significant in only 2 tissues. Subchronic DFO infusion appears to be beneficial in A1-loaded subjects but not without potential for further toxicity.
J M Melograna, and
R A Yokel
January 1988,
ASAIO transactions,
J M Melograna, and
R A Yokel
September 2021,
Pharmaceuticals (Basel, Switzerland),
J M Melograna, and
R A Yokel
January 1982,
Drug and chemical toxicology,
J M Melograna, and
R A Yokel
September 1987,
Clinical nephrology,
J M Melograna, and
R A Yokel
January 1982,
Drug and chemical toxicology,
J M Melograna, and
R A Yokel
January 1984,
Transactions - American Society for Artificial Internal Organs,
J M Melograna, and
R A Yokel
April 1989,
Lancet (London, England),
J M Melograna, and
R A Yokel
October 1989,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
J M Melograna, and
R A Yokel
January 1990,
Blood purification,
J M Melograna, and
R A Yokel
March 2012,
Biological trace element research,
