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The rat serum protein that undergoes Ca2+-dependent binding to pneumococcal C-polysaccharide and to phosphocholine residues, and that is evidently a member of the pentraxin family of proteins by virtue of its appearance under the electron microscope, has been variously designated as rat C-reactive protein (CRP) [de Beer, Baltz, Munn, Feinstein, Taylor, Bruton, Clamp & Pepys (1982) Immunology 45, 55-70], 'phosphoryl choline-binding protein' [Nagpurkar & Mookerjea (1981) J. Biol. Chem. 256, 7440-7448] and rat serum amyloid P component (SAP) [Pontet, D'Asnieres, Gache, Escaig & Engler (1981) Biochim. Biophys. Acta 671, 202-210]. The partial amino acid sequence (45 residues) towards the C-terminus of this protein was determined, and it showed 71.7% identity with the known sequence of human CRP but only 54.3% identity with human SAP. Since human CRP and SAP are themselves approximately 50% homologous, the level of identity between the rat protein and human SAP is evidence only of membership of the pentraxin family. In contrast, the much greater resemblance to human CRP confirms that the rat C-polysaccharide-binding/phosphocholine-binding protein is in fact rat CRP.
J A Taylor, and
C J Bruton, and
J K Anderson, and
J E Mole, and
F C De Beer, and
M L Baltz, and
M B Pepys
September 1986,
Biochemical and biophysical research communications,
J A Taylor, and
C J Bruton, and
J K Anderson, and
J E Mole, and
F C De Beer, and
M L Baltz, and
M B Pepys
July 1983,
Biochemical and biophysical research communications,
J A Taylor, and
C J Bruton, and
J K Anderson, and
J E Mole, and
F C De Beer, and
M L Baltz, and
M B Pepys
January 1985,
Comparative biochemistry and physiology. B, Comparative biochemistry,
J A Taylor, and
C J Bruton, and
J K Anderson, and
J E Mole, and
F C De Beer, and
M L Baltz, and
M B Pepys
April 1981,
The Journal of clinical investigation,
J A Taylor, and
C J Bruton, and
J K Anderson, and
J E Mole, and
F C De Beer, and
M L Baltz, and
M B Pepys
June 1987,
Endocrinology,
J A Taylor, and
C J Bruton, and
J K Anderson, and
J E Mole, and
F C De Beer, and
M L Baltz, and
M B Pepys
July 1984,
Biochemical and biophysical research communications,
J A Taylor, and
C J Bruton, and
J K Anderson, and
J E Mole, and
F C De Beer, and
M L Baltz, and
M B Pepys
March 1979,
Journal of theoretical biology,
J A Taylor, and
C J Bruton, and
J K Anderson, and
J E Mole, and
F C De Beer, and
M L Baltz, and
M B Pepys
January 1990,
FEBS letters,
J A Taylor, and
C J Bruton, and
J K Anderson, and
J E Mole, and
F C De Beer, and
M L Baltz, and
M B Pepys
October 1971,
FEBS letters,
J A Taylor, and
C J Bruton, and
J K Anderson, and
J E Mole, and
F C De Beer, and
M L Baltz, and
M B Pepys
January 1978,
Scandinavian journal of immunology,
