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Absorption of sodium [1-14C]glycolate by rat intestine was studied by using the tissue accumulation technique with everted intestinal rings. Saturation kinetics was observed for the absorption of glycolate in the jejunoileal region, with a Km of 6.25 mM for glycolate and a Vmax of 5.56 mumole/30 min/g wet wt. The absorption was linear up to a period of 25 min at 37 degrees C. Jejunum and ileum showed significantly higher absorption of glycolate as compared to colon. Sulfhydryl binding agents, viz., p-chloromercuribenzoate and iodoacetate, and respiration inhibitors, e.g., KCN and 2,4-dinitrophenol, had no significant effect on glycolate uptake. However, glyoxylate and lactate showed significant inhibition at 6 mM concentration of the inhibitor. Pyridoxine deficiency had no effect on glycolate uptake by the rat intestine.
H S Talwar, and
M S Murthy, and
S K Thind, and
R Nath
October 1966,
The American journal of physiology,
H S Talwar, and
M S Murthy, and
S K Thind, and
R Nath
July 2013,
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,
H S Talwar, and
M S Murthy, and
S K Thind, and
R Nath
January 1982,
Acta paediatrica Scandinavica,
H S Talwar, and
M S Murthy, and
S K Thind, and
R Nath
January 1973,
Nursing Research Conference,
H S Talwar, and
M S Murthy, and
S K Thind, and
R Nath
March 1968,
The Journal of physiology,
H S Talwar, and
M S Murthy, and
S K Thind, and
R Nath
November 1956,
Klinische Wochenschrift,
H S Talwar, and
M S Murthy, and
S K Thind, and
R Nath
May 1977,
Developmental biology,
H S Talwar, and
M S Murthy, and
S K Thind, and
R Nath
October 1990,
Journal of pediatric gastroenterology and nutrition,
H S Talwar, and
M S Murthy, and
S K Thind, and
R Nath
September 1987,
Japanese journal of pharmacology,
H S Talwar, and
M S Murthy, and
S K Thind, and
R Nath
January 1969,
Gut,
