Biomaterial Database

Mercury concentration in the blood and organs of normal and acatalasemic mice after intraperitoneal injection of metallic mercury (203Hg0). 1984

M Ogata, and H Aikoh

The total amount of mercury exhaled from acatalasemic mice in ten minutes after injection of metallic mercury was about 1.6 times higher than that of normal mice. The level of metallic mercury in the blood of acatalasemic mice was significantly higher than that of normal mice. The levels of mercury in the brain and liver in acatalasemic mice in ten minutes after injection of metallic mercury, and the brain/blood ratio or liver/blood ratio of mercury in acatalasemic mice were significantly higher than those of normal mice. These results suggest that metallic mercury in the blood readily passes through the blood-brain or blood-liver barrier.

UI	MeSH Term	Description	Entries
D007274	Injections, Intraperitoneal	Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.	Intraperitoneal Injections,Injection, Intraperitoneal,Intraperitoneal Injection
D008628	Mercury	A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
D008631	Mercury Radioisotopes	Unstable isotopes of mercury that decay or disintegrate emitting radiation. Hg atoms with atomic weights 185-195, 197, 203, 205, and 206 are radioactive mercury isotopes.	Radioisotopes, Mercury
D008809	Mice, Inbred C3H	An inbred strain of mouse that is used as a general purpose strain in a wide variety of RESEARCH areas including CANCER; INFECTIOUS DISEASES; sensorineural, and cardiovascular biology research.	Mice, C3H,Mouse, C3H,Mouse, Inbred C3H,C3H Mice,C3H Mice, Inbred,C3H Mouse,C3H Mouse, Inbred,Inbred C3H Mice,Inbred C3H Mouse
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D020642	Acatalasia	A rare autosomal recessive disorder resulting from the absence of CATALASE activity. Though usually asymptomatic, a syndrome of oral ulcerations and gangrene may be present.	Acatalasemia,Hypocatalasemia,Acatalasemia Japanese Type,Acatalasemia Swiss Type,Catalase Deficiency,Hypocatalasia,Takahara Disease,Takahara's Disease,Catalase Deficiencies,Deficiencies, Catalase,Deficiency, Catalase,Disease, Takahara,Disease, Takahara's,Japanese Type, Acatalasemia,Swiss Type, Acatalasemia,Takaharas Disease