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The extracellular calcium antagonists, nifedipine and verapamil, the mixed extra/intracellular calcium antagonist diazoxide and the intracellular calcium antagonist TMB-8 were studied for their effects on histamine-induced bronchospasm in guinea pigs and on antigen-induced bronchospasms in guinea pigs and rats when administered directly to the tracheobronchial tree. Nifedipine and verapamil inhibited histamine and antigen-induced bronchoconstriction in guinea pigs, and verapamil was effective in preventing antigen-induced bronchospasms in rats. However, using doses of the extracellular blockers which produce these pulmonary effects, significant reduction of blood pressure occurred in both guinea pigs and rats. Diazoxide was inactive against histamine and antigen-induced bronchoconstrictions in guinea pigs. TMB-8 was inactive against histamine and antigen-induced bronchospasm in guinea pigs and rats. These studies demonstrate the antibronchoconstrictor activity of extracellular Ca2+ antagonists in guinea pigs and rats, but indicate that intracellular Ca2+ antagonists are not antibronchospastic agents in these species in vivo.
R W Chapman, and
G Danko, and
M I Siegel
September 1950,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
R W Chapman, and
G Danko, and
M I Siegel
January 1968,
Farmakologiia i toksikologiia,
R W Chapman, and
G Danko, and
M I Siegel
June 1951,
Gastroenterology,
R W Chapman, and
G Danko, and
M I Siegel
January 1990,
Farmakologiia i toksikologiia,
R W Chapman, and
G Danko, and
M I Siegel
January 1956,
The Journal of physiology,
R W Chapman, and
G Danko, and
M I Siegel
October 1990,
The Journal of allergy and clinical immunology,
R W Chapman, and
G Danko, and
M I Siegel
January 1993,
The American review of respiratory disease,
R W Chapman, and
G Danko, and
M I Siegel
November 1996,
International archives of allergy and immunology,
R W Chapman, and
G Danko, and
M I Siegel
May 1949,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R W Chapman, and
G Danko, and
M I Siegel
June 1979,
The Journal of pharmacy and pharmacology,
