BIOMAT Database Logo BIOMAT Database Logo

Coronary artery spasm and cardiac arrest in carcinoid heart disease. 1984

E J Topol, and N J Fortuin

Previously reported cardiac manifestations of carcinoid disease include right-sided valvular dysfunction and vasomotor disturbances. This report describes a 62-year-old white man who had electrocardiographically documented widespread elevation of the S-T segment, arrhythmias, and cardiac arrest after exercise. Noninvasive and laboratory studies confirmed the diagnosis of malignant carcinoid disease with tricuspid valve involvement. Coronary angiography revealed mild atherosclerosis. Thus, coronary artery spasm is a previously unrecognized manifestation of carcinoid heart disease and introduces what may be an important relationship of endogenous, excessive vasoactive amines to human coronary vasospasm.

UI MeSH Term Description Entries
D008297 Male Males
D008303 Malignant Carcinoid Syndrome A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed) Carcinoid Syndrome, Malignant,Carcinoid Syndromes, Malignant,Malignant Carcinoid Syndromes,Syndrome, Malignant Carcinoid,Syndromes, Malignant Carcinoid
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002275 Carcinoid Heart Disease Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation. Carcinoid Heart Diseases,Heart Disease, Carcinoid,Heart Diseases, Carcinoid
D003329 Coronary Vasospasm Spasm of the large- or medium-sized coronary arteries. Coronary Artery Spasm,Coronary Artery Vasospasm,Artery Spasm, Coronary,Artery Vasospasm, Coronary,Coronary Artery Spasms,Coronary Artery Vasospasms,Coronary Vasospasms,Spasm, Coronary Artery,Vasospasm, Coronary,Vasospasm, Coronary Artery
D006323 Heart Arrest Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation. Asystole,Cardiac Arrest,Cardiopulmonary Arrest,Arrest, Cardiac,Arrest, Cardiopulmonary,Arrest, Heart,Asystoles
D006632 Histamine An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. Ceplene,Histamine Dihydrochloride,Histamine Hydrochloride,Peremin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

E J Topol, and N J Fortuin
Coronary artery spasm and perioperative cardiac arrest.
August 1980, The Journal of thoracic and cardiovascular surgery,
E J Topol, and N J Fortuin
Cardiac arrest associated with coronary artery spasm.
December 1987, The American journal of cardiology,
E J Topol, and N J Fortuin
Coronary artery spasm, silent ischemia, and cardiac arrest.
May 1992, The New England journal of medicine,
E J Topol, and N J Fortuin
Coronary artery spasm in survivors of cardiac arrest.
May 1993, Japanese heart journal,
E J Topol, and N J Fortuin
Coronary spasm and cardiac arrest from carcinoid crisis during laser bronchoscopy.
February 1999, Chest,
E J Topol, and N J Fortuin
High prevalence of coronary artery spasm in survivors of cardiac arrest with no apparent heart disease.
September 1992, Japanese heart journal,
E J Topol, and N J Fortuin
Perioperative multivessel coronary artery spasm and cardiac arrest after cardiac surgery.
May 2024, Interdisciplinary cardiovascular and thoracic surgery,
E J Topol, and N J Fortuin
Coronary artery spasm is a major cause of sudden cardiac arrest in survivors without underlying heart disease.
February 1993, Coronary artery disease,
E J Topol, and N J Fortuin
Pre-hospital cardiac arrest associated with coronary artery spasm.
January 1993, International journal of cardiology,
E J Topol, and N J Fortuin
[Intraoperative coronary artery spasm with cardiac arrest: cardiologic acute intervention].
March 2008, Der Anaesthesist,
Copied contents to your clipboard!