Strategies for pooling data in occupational epidemiological studies. 1984

J R Goldsmith, and S Beeser

In occupational epidemiology, most of the populations at risk are of limited size, and therefore pooling of the experience of different groups with similar exposure is desirable. We present and compare five different strategies for pooling of such data, including the "default" strategy of present reporting practices, which have the disadvantage that the experience of many small units is not recorded because of the low statistical power of small populations. A simple summation strategy including cases and controls from diverse groups, while attractively simple, may be fallacious when cases and controls have different proportions which are confounded with the risk ratios. Separate summation of observed and expected numbers of cases avoids the risk of fallacy, but may be unduly influenced by the results in one large plant. A "Clinical Trial" type of strategy in which all of the data are collected by a common protocol and therefore considered as a single data set is administratively complex and does not seem well suited for occupational epidemiology. Probability pooling seems to have attractive features, avoiding most of the disadvantages of the other strategies, and having the added feature that weighting for exposure and duration of follow-up can be included. Probability pooling requires exact probability statements for each study. Examples are given for pooling of data from exposures of operating room personnel to anaesthetic agents, cohorts of workers exposed to asbestos, and cohorts of workers exposed to man-made mineral fibres. A working group is proposed to recommend procedures and to assist in interpreting pooling activities.

UI MeSH Term Description Entries
D008297 Male Males
D009784 Occupational Diseases Diseases caused by factors involved in one's employment. Diseases, Occupational,Occupational Illnesses,Disease, Occupational,Illnesse, Occupational,Illnesses, Occupational,Occupational Disease,Occupational Illnesse
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D012140 Respiratory Tract Diseases Diseases involving the RESPIRATORY SYSTEM. Respiratory Diseases,Respiratory System Diseases,Disease, Respiratory System,Disease, Respiratory Tract,Respiratory System Disease,Respiratory Tract Disease
D012142 Respiratory Tract Neoplasms Tumors or cancer of the RESPIRATORY SYSTEM. Respiratory Neoplasms,Respiratory System Neoplasms,Neoplasm, Respiratory,Neoplasm, Respiratory System,Neoplasm, Respiratory Tract,Respiratory Neoplasm,Respiratory System Neoplasm,Respiratory Tract Neoplasm
D004812 Epidemiologic Methods Research techniques that focus on study designs and data gathering methods in human and animal populations. Epidemiologic Method,Epidemiological Methods,Methods, Epidemiologic,Epidemiological Method,Method, Epidemiologic,Method, Epidemiological,Methods, Epidemiological
D005260 Female Females
D005898 Glass Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000014 Abnormalities, Drug-Induced Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. Drug-Induced Abnormalities,Abnormalities, Drug Induced,Abnormality, Drug-Induced,Drug Induced Abnormalities,Drug-Induced Abnormality

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