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The effects of xylitol on the rate of gastric emptying and plasma gastric inhibitory polypeptide secretion in the rat were studied to relate xylitol adaptation to these phenomena. Male Sprague-Dawley rats, weighing about 250-270 g, were either gradually adapted to 20% xylitol diets or given a basal diet. The animals were, after a 24-hour fast, given a 1.2 g/kg body weight dose of xylitol or glucose either alone or with a 99mTc-tin colloid marker to study gastric emptying by using a gamma camera. Blood was taken from the tail vein, and plasma was analyzed for immunoreactive gastric inhibitory polypeptide by using a double-antibody radioimmunoassay. Xylitol adaptation did not appear to have any effect on the secretion of gastric inhibitory polypeptide. However, adaptation of rats to 20% dietary xylitol appeared to change the rate of gastric emptying by decreasing it. Therefore, it was concluded that gastric emptying plays a role in the adaptation to high xylitol doses while gastric inhibitory polypeptide appears not to be involved.
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