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Many nucleoside analogs were screened for anti-protozoa activity on Leishmania tropica in an in vitro culture system. 3'-Deoxyinosine and several tubercidin derivatives were found to be potent inhibitors for growth of the promastigote form of L. tropica. EC50 value of 3'-deoxyinosine was 4.43 X 10(-7)M. This compound was remarkably less toxic towards mouse mammary tumor FM3A cells (EC50, 1.25 X 10(-4) M). 3'-Deoxyinosine is metabolized by Leishmania promastigote to give 3'-deoxyinosine-5'-monophosphate, 3'-deoxy-adenosine(cordycepin)-5'-mono, di-, and triphosphates. This means that Leishmania can aminate the 6-position of 3'-deoxyinosine-5'-monophosphate, thereby converting it into a highly toxic compound.
Y Wataya, and
O Hiraoka, and
Y Sonobe, and
A Yoshioka, and
A Matsuda, and
T Miyasaka, and
M Saneyoshi, and
T Ueda
January 2009,
Turkiye parazitolojii dergisi,
Y Wataya, and
O Hiraoka, and
Y Sonobe, and
A Yoshioka, and
A Matsuda, and
T Miyasaka, and
M Saneyoshi, and
T Ueda
January 1983,
Molecular and biochemical parasitology,
Y Wataya, and
O Hiraoka, and
Y Sonobe, and
A Yoshioka, and
A Matsuda, and
T Miyasaka, and
M Saneyoshi, and
T Ueda
February 1976,
Experimental parasitology,
Y Wataya, and
O Hiraoka, and
Y Sonobe, and
A Yoshioka, and
A Matsuda, and
T Miyasaka, and
M Saneyoshi, and
T Ueda
June 1977,
Experimental parasitology,
Y Wataya, and
O Hiraoka, and
Y Sonobe, and
A Yoshioka, and
A Matsuda, and
T Miyasaka, and
M Saneyoshi, and
T Ueda
February 1979,
The Journal of protozoology,
Y Wataya, and
O Hiraoka, and
Y Sonobe, and
A Yoshioka, and
A Matsuda, and
T Miyasaka, and
M Saneyoshi, and
T Ueda
May 1987,
Molecular and biochemical parasitology,
Y Wataya, and
O Hiraoka, and
Y Sonobe, and
A Yoshioka, and
A Matsuda, and
T Miyasaka, and
M Saneyoshi, and
T Ueda
October 1974,
The Journal of protozoology,
Y Wataya, and
O Hiraoka, and
Y Sonobe, and
A Yoshioka, and
A Matsuda, and
T Miyasaka, and
M Saneyoshi, and
T Ueda
September 1983,
Molecular and biochemical parasitology,
Y Wataya, and
O Hiraoka, and
Y Sonobe, and
A Yoshioka, and
A Matsuda, and
T Miyasaka, and
M Saneyoshi, and
T Ueda
September 1978,
Tropenmedizin und Parasitologie,
Y Wataya, and
O Hiraoka, and
Y Sonobe, and
A Yoshioka, and
A Matsuda, and
T Miyasaka, and
M Saneyoshi, and
T Ueda
October 1986,
Molecular and biochemical parasitology,
