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The conformational changes induced by the binding of cis-diamminedichloroplatinum(II) to poly(dG-dC).poly(dG-dC) have been studied by reaction with specific antibodies, by circular dichroism and 31P nuclear magnetic resonance. Polyclonal and monoclonal antibodies to Z-DNA bind to platinated poly(dG-dC).poly(dG-dC) at low and high ionic strength. Antibodies elicited in rabbits immunized with the platinated polynucleotide bind to double stranded polynucleotides known to adopt the Z-conformation. At low and high ionic strength the circular dichroism spectrum of platinated poly(dG-dC).poly(dG- dC) does not resemble that of poly(dG-dC).poly(dG-dC) (B or Z conformation). At low ionic strength, the characteristic 31P nuclear magnetic resonance spectrum of the Z-form is not detected. It appears only at high ionic strength, as a component of a more complex spectrum.
J M Malinge, and
M Ptak, and
M Leng
October 1985,
Journal of biomolecular structure & dynamics,
J M Malinge, and
M Ptak, and
M Leng
November 1984,
Nucleic acids research,
J M Malinge, and
M Ptak, and
M Leng
November 1981,
Nucleic acids research,
J M Malinge, and
M Ptak, and
M Leng
March 1981,
Nucleic acids research,
J M Malinge, and
M Ptak, and
M Leng
January 1984,
The Journal of biological chemistry,
J M Malinge, and
M Ptak, and
M Leng
March 1986,
Biopolymers,
J M Malinge, and
M Ptak, and
M Leng
October 1984,
Nucleic acids research,
J M Malinge, and
M Ptak, and
M Leng
January 1983,
Biochimica et biophysica acta,
J M Malinge, and
M Ptak, and
M Leng
October 1985,
Biochemistry,
J M Malinge, and
M Ptak, and
M Leng
March 1978,
Nucleic acids research,
