-transparent.png){kind=logo}
Methionine-enkephalin (0.2--20 microgram/rat) and leucine-enkephalin (1--20 microgram/rat) produced a dose-related and naloxone-antagonizable analgesia in the tail-pinch test, when microinjected into the nucleus reticularis gigantocellularis (NRGC) and nucleus reticularis paragigantocellularis (NRPG) of the medulla oblongata of the rat. The median analgesic doses were 1.4 and 4.8 microgram/rat for methionine- leucine-enkephalin, respectively. The possibility that the endogenous enkephalins play a part as pain control substances or modulators in the NRGC and NRPG was discussed.
Related Publications
H Takagi, and
M Satoh, and
A Akaike, and
T Shibata, and
H Yajima, and
H Ogawa
December 1983,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
H Takagi, and
M Satoh, and
A Akaike, and
T Shibata, and
H Yajima, and
H Ogawa
January 1978,
Biochemical pharmacology,
H Takagi, and
M Satoh, and
A Akaike, and
T Shibata, and
H Yajima, and
H Ogawa
March 1995,
Neuroscience,
H Takagi, and
M Satoh, and
A Akaike, and
T Shibata, and
H Yajima, and
H Ogawa
January 1990,
Brain research bulletin,
H Takagi, and
M Satoh, and
A Akaike, and
T Shibata, and
H Yajima, and
H Ogawa
March 1978,
Archives internationales de pharmacodynamie et de therapie,
H Takagi, and
M Satoh, and
A Akaike, and
T Shibata, and
H Yajima, and
H Ogawa
December 1966,
Brain research,
H Takagi, and
M Satoh, and
A Akaike, and
T Shibata, and
H Yajima, and
H Ogawa
February 1984,
Brain research,
H Takagi, and
M Satoh, and
A Akaike, and
T Shibata, and
H Yajima, and
H Ogawa
September 1993,
Neuroscience letters,
H Takagi, and
M Satoh, and
A Akaike, and
T Shibata, and
H Yajima, and
H Ogawa
January 1978,
Brain research bulletin,
H Takagi, and
M Satoh, and
A Akaike, and
T Shibata, and
H Yajima, and
H Ogawa
June 1986,
Neuroscience letters,
