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In a sample of 26 inpatients (15 primary endogenous depressives and a heterogeneous comparison group of 11 psychiatric patients), results of the dexamethasone suppression test (DST) for endogenous depression were compared when cortisol was measured in plasma (total and free) and in saliva. Results showed a close linear relationship among plasma total and free cortisol, plasma total cortisol, and saliva cortisol, and between free plasma and saliva cortisol. A saliva cortisol cutoff point of 70 ng/dl achieved the same sensitivity (67%), specificity (91%), and diagnostic confidence (91%) as the best cutoff scores of plasma total cortisol (5 micrograms/dl) and plasma free cortisol (0.15 microgram/dl). These results suggest that saliva cortisol, which directly reflects the biologically active fraction of cortisol, can be used as a reliable and more practical index in the DST, especially in outpatients.
M Ansseau, and
J Sulon, and
A Doumont, and
J L Cerfontaine, and
J J Legros, and
J C Sodoyez, and
E Demey-Ponsart
June 1987,
Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology,
M Ansseau, and
J Sulon, and
A Doumont, and
J L Cerfontaine, and
J J Legros, and
J C Sodoyez, and
E Demey-Ponsart
January 2001,
Physiology & behavior,
M Ansseau, and
J Sulon, and
A Doumont, and
J L Cerfontaine, and
J J Legros, and
J C Sodoyez, and
E Demey-Ponsart
June 1987,
The Japanese journal of psychiatry and neurology,
M Ansseau, and
J Sulon, and
A Doumont, and
J L Cerfontaine, and
J J Legros, and
J C Sodoyez, and
E Demey-Ponsart
October 1990,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
M Ansseau, and
J Sulon, and
A Doumont, and
J L Cerfontaine, and
J J Legros, and
J C Sodoyez, and
E Demey-Ponsart
January 1985,
Psychoneuroendocrinology,
M Ansseau, and
J Sulon, and
A Doumont, and
J L Cerfontaine, and
J J Legros, and
J C Sodoyez, and
E Demey-Ponsart
May 1984,
The American journal of psychiatry,
M Ansseau, and
J Sulon, and
A Doumont, and
J L Cerfontaine, and
J J Legros, and
J C Sodoyez, and
E Demey-Ponsart
January 1987,
Acta psychiatrica Belgica,
M Ansseau, and
J Sulon, and
A Doumont, and
J L Cerfontaine, and
J J Legros, and
J C Sodoyez, and
E Demey-Ponsart
April 1988,
Biological psychiatry,
M Ansseau, and
J Sulon, and
A Doumont, and
J L Cerfontaine, and
J J Legros, and
J C Sodoyez, and
E Demey-Ponsart
October 1984,
The Journal of clinical psychiatry,
M Ansseau, and
J Sulon, and
A Doumont, and
J L Cerfontaine, and
J J Legros, and
J C Sodoyez, and
E Demey-Ponsart
May 1983,
Archives of general psychiatry,
