Biomaterial Database

Stimulation by epidermal growth factor of phospholipid methyltransferase in isolated rat hepatocytes. 1983

V A Chiva, and D M Cao, and J M Mato

Epidermal growth factor produces a time- and dose-dependent activation of phospholipid methyltransferase activity in hepatocytes isolated from juvenile and mature hepatectomized rats. This treatment however has no effect with hepatocytes isolated from mature or laparotomized rats. Dansylcadaverine (50 microM), an inhibitor of receptor-mediated internalization of epidermal growth factor, has no effect on basal phospholipid methyltransferase but inhibits the stimulation of this enzyme by epidermal growth factor. These results indicate a possible role of phospholipid methylation during liver proliferation.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008115	Liver Regeneration	Repair or renewal of hepatic tissue.	Liver Regenerations,Regeneration, Liver,Regenerations, Liver
D008780	Methyltransferases	A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.	Methyltransferase
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D004789	Enzyme Activation	Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.	Activation, Enzyme,Activations, Enzyme,Enzyme Activations
D004815	Epidermal Growth Factor	A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.	EGF,Epidermal Growth Factor-Urogastrone,Urogastrone,Human Urinary Gastric Inhibitor,beta-Urogastrone,Growth Factor, Epidermal,Growth Factor-Urogastrone, Epidermal,beta Urogastrone
D000375	Aging	The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	Senescence,Aging, Biological,Biological Aging
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D050918	Phosphatidylethanolamine N-Methyltransferase	An enzyme that catalyses three sequential METHYLATION reactions for conversion of phosphatidylethanolamine to PHOSPHATIDYLCHOLINE.	Cephalin N-Methyltransferase,PHET Methyltransferase II,Phosphatidylethanolamine Methyltransferase,Phosphatidylethanolamine N-Methyltransferase-2,Phosphatidylethanolamine-Methyltransferase II,Phosphatidylethanolamine-Phosphatidylcholine N-Methyltransferase,Phospholipid Methyltransferase II,S-Adenosylmethionine Phosphatidylethanolamine N-Methyltransferase,Cephalin N Methyltransferase,Methyltransferase II, PHET,Methyltransferase II, Phospholipid,Methyltransferase, Phosphatidylethanolamine,N-Methyltransferase, Cephalin,N-Methyltransferase, Phosphatidylethanolamine,N-Methyltransferase, Phosphatidylethanolamine-Phosphatidylcholine,N-Methyltransferase, S-Adenosylmethionine Phosphatidylethanolamine,N-Methyltransferase-2, Phosphatidylethanolamine,Phosphatidylethanolamine Methyltransferase II,Phosphatidylethanolamine N Methyltransferase,Phosphatidylethanolamine N Methyltransferase 2,Phosphatidylethanolamine N-Methyltransferase, S-Adenosylmethionine,Phosphatidylethanolamine Phosphatidylcholine N Methyltransferase,S Adenosylmethionine Phosphatidylethanolamine N Methyltransferase